Journal article
Lethality of the double mutations rho rep and rho ssb in Escherichia coli
Journal of bacteriology, Vol.161(2), pp.609-614
1985
DOI: 10.1128/jb.161.2.609-614.1985
PMCID: PMC214926
PMID: 3155723
Abstract
The similarity of rho mutants to rep and ssb mutants in sensitivity to UV light and in recombination deficiency suggested that the function of the Rho protein might be related to that of Rep and Ssb. In support of that idea, we found that rho rep and rho ssb double mutants are either nonviable, or at best only marginally viable. Viability could be restored by suppressor mutations, one of which mapped either in the rho gene or close to its 5'-end. Rho may thus share a role with Rep and Ssb in replication and the structural maintenance of DNA; a multifunctional Rho protein could account for the diversity of the defects seen in rho mutants, some of which appear to have no relation to the defect in transcription termination.
Details
- Title: Subtitle
- Lethality of the double mutations rho rep and rho ssb in Escherichia coli
- Creators
- J. S Fassler - Purdue univ., dep. biological sciI Tessman - Purdue univ., dep. biological sciE. S Tessman - Purdue univ., dep. biological sci
- Resource Type
- Journal article
- Publication Details
- Journal of bacteriology, Vol.161(2), pp.609-614
- Publisher
- American Society for Microbiology
- DOI
- 10.1128/jb.161.2.609-614.1985
- PMID
- 3155723
- PMCID
- PMC214926
- ISSN
- 0021-9193
- eISSN
- 1098-5530
- Language
- English
- Date published
- 1985
- Academic Unit
- Biology
- Record Identifier
- 9984217427402771
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