Leucocyte sodium content and sodium pump activity in overweight and lean hypertensives

L L Ng; M Harker; E D Abel

doi:10.1111/j.1365-2265.1989.tb03741.x

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Leucocyte sodium content and sodium pump activity in overweight and lean hypertensives

Journal article

Peer reviewed

Leucocyte sodium content and sodium pump activity in overweight and lean hypertensives

L L Ng, M Harker and E D Abel

Clinical endocrinology (Oxford), Vol.30(2), pp.191-200

02/1989

DOI: 10.1111/j.1365-2265.1989.tb03741.x

PMID: 2612017

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Abstract

Leucocyte sodium content and sodium pump activity was studied in overweight and lean hypertensive subjects and normotensive controls, all in the fasting state. In lean subjects (body mass index less than 27 kg m-2), hypertensives did not have altered leucocyte sodium content or pump activity. In the overweight (mostly obese) subjects, the leucocyte sodium content was higher in hypertensive than in normotensive subjects (median (range) 56.1 (42.0-84.1) vs 32.0 (18.2-59.4) mmol kg-1, P less than 0.001). This raised sodium content in overweight hypertensives was associated with a lower (ouabain-sensitive) 22Na efflux rate constant (2.25 (1.15-3.01) vs 2.64 (1.98-3.61) h-1, P less than 0.05) and a higher passive (or ouabain-insensitive) 22Na efflux rate constant (0.90(0.53-1.18) vs 0.63 (0.21-1.09) h-1, P less than 0.01). The systolic and diastolic blood pressures were significantly correlated to intracellular Na+ in the overweight group (r = 0.41 and 0.56, P less than 0.02 and 0.001 respectively). Thus, hypertension in the overweight subjects is associated with accumulation of intracellular sodium that may be due to abnormalities of the active sodium pump, though changes in ouabain-insensitive mechanisms also occur.

Hypertension - blood

Obesity - complications

Humans

Middle Aged

Hypertension - complications

Leukocytes - analysis

Female

Male

Biological Transport - drug effects

Obesity - blood

Ouabain - pharmacology

Sodium - blood

Details

Title: Subtitle: Leucocyte sodium content and sodium pump activity in overweight and lean hypertensives
Creators: L L Ng - Sheikh Rashid Diabetes Unit, Radcliffe Infirmary, Oxford, UK
M Harker
E D Abel
Resource Type: Journal article
Publication Details: Clinical endocrinology (Oxford), Vol.30(2), pp.191-200
Publisher: England
DOI: 10.1111/j.1365-2265.1989.tb03741.x
PMID: 2612017
ISSN: 0300-0664
eISSN: 1365-2265
Language: English
Date published: 02/1989
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984024515602771

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