Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman

Bryan Steussy; Jacqueline Lekostaj; Qining Qian; Nancy Rosenthal; Carol J Holman; Sergei Syrbu; Benjamin Darbro; Aaron Bossler; Nitin J Karandikar

doi:10.1093/labmed/lmw011

Back

Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman

Journal article

Open access

Peer reviewed

Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman

Bryan Steussy, Jacqueline Lekostaj, Qining Qian, Nancy Rosenthal, Carol J Holman, Sergei Syrbu, Benjamin Darbro, Aaron Bossler and Nitin J Karandikar

Laboratory medicine, Vol.47(2), pp.155-157

05/2016

DOI: 10.1093/labmed/lmw011

PMCID: PMC7243928

PMID: 27069033

Files and links (1)

url

https://doi.org/10.1093/labmed/lmw011View

Published (Version of record) Open Access

Abstract

We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M(5)c)-like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm.

5-Methylcytosine

Humans

Middle Aged

Lymphoma, Follicular - diagnosis

B-Lymphocytes - physiology

Leukemia, Monocytic, Acute - genetics

Cell Lineage

Lymphoma, Follicular - genetics

Leukemia, Monocytic, Acute - diagnosis

Cell Transdifferentiation

Female

Clone Cells

Histiocytes - physiology

Karyotype

Details

Title: Subtitle: Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman
Creators: Bryan Steussy - Department of Pathology, University of Iowa, Iowa City
Jacqueline Lekostaj - Department of Pathology, University of Iowa, Iowa City
Qining Qian - Department of Pathology, University of Iowa, Iowa City
Nancy Rosenthal - Department of Pathology, University of Iowa, Iowa City
Carol J Holman - Department of Pathology, University of Iowa, Iowa City
Sergei Syrbu - Department of Pathology, University of Iowa, Iowa City
Benjamin Darbro - Department of Pathology, University of Iowa, Iowa City
Aaron Bossler - Department of Pathology, University of Iowa, Iowa City
Nitin J Karandikar - Department of Pathology, University of Iowa, Iowa City nitin-karandikar@uiowa.edu
Resource Type: Journal article
Publication Details: Laboratory medicine, Vol.47(2), pp.155-157
DOI: 10.1093/labmed/lmw011
PMID: 27069033
PMCID: PMC7243928
NLM abbreviation: Lab Med
ISSN: 0007-5027
eISSN: 1943-7730
Publisher: England
Grant note: P30 CA086862 / NCI NIH HHS
Language: English
Date published: 05/2016
Academic Unit: Stead Family Department of Pediatrics; Pathology; Medical Genetics and Genomics
Record Identifier: 9984046909502771

Metrics

30 Record Views

7 Times Cited - Web of Science