Journal article
Leukocyte cell population data from the blood cell analyzer as a predictive marker for severity of acute pancreatitis
Journal of clinical laboratory analysis, Vol.35(7), pp.e23863-n/a
07/2021
DOI: 10.1002/jcla.23863
PMCID: PMC8274994
PMID: 34062621
Abstract
Background The prediction for severe acute pancreatitis (SAP) is the key to give timely targeted treatment. Leukocyte cell population data (CPD) have been widely applied in early prediction and diagnosis of many diseases, but their predictive ability for SAP remains unexplored. We aim to testify whether CPD could be an indicator of AP severity in the early stage of the disease.
Methods The prospective observational study was conducted in the emergency department ward of a territory hospital in Shanghai. The enrolled AP patients should meet 2012 Atlanta guideline.
Results Totally, 103 AP patients and 62 healthy controls were enrolled and patients were classified into mild AP (n = 30), moderate SAP (n = 42), and SAP (n = 31). Forty-two CPD parameters were examined in first 3 days of admission. Four CPD parameters were highest in SAP on admission and were constantly different among 3 groups during first 3 days of hospital stay. Eighteen CPD parameters were found correlated with the occurrence of SAP. Stepwise multivariate logistic regression analysis identified a scoring system of 4 parameters (SD_LALS_NE, MN_LALS_LY, SD_LMALS_MO, and SD_AL2_MO) with a sensitivity of 96.8%, specificity of 65.3%, and AUC of 0.87 for diagnostic accuracy on early identification of SAP. AUC of this scoring system was comparable with MCTSI, SOFA, APACHE II, MMS, BISAP, or biomarkers as CRP, PCT, and WBC in prediction of SAP and ICU transfer or death.
Conclusions Several leukocyte CPD parameters have been identified different among MAP, MSAP, and SAP. They might be ultimately incorporated into a predictive system marker for severity of AP.
Details
- Title: Subtitle
- Leukocyte cell population data from the blood cell analyzer as a predictive marker for severity of acute pancreatitis
- Creators
- Yihui Wang - Ruijin HospitalZhihong Xu - Ruijin HospitalYuhua Zhou - Ruijin HospitalMengqi Xie - Ruijin HospitalXing Qi - Shanghai Jiao Tong UniversityZhiwei Xu - Ruijin HospitalQi Cai - Shanghai Jiao Tong UniversityHuiqiu Sheng - Ruijin HospitalErzhen Chen - Shanghai Jiao Tong UniversityBing Zhao - Ruijin HospitalEnqiang Mao - Ruijin Hospital
- Resource Type
- Journal article
- Publication Details
- Journal of clinical laboratory analysis, Vol.35(7), pp.e23863-n/a
- DOI
- 10.1002/jcla.23863
- PMID
- 34062621
- PMCID
- PMC8274994
- NLM abbreviation
- J Clin Lab Anal
- ISSN
- 0887-8013
- eISSN
- 1098-2825
- Publisher
- Wiley
- Number of pages
- 15
- Grant note
- 81601665 / National Natural Science Foundation Youth Project of China 81600501 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC)
- Language
- English
- Date published
- 07/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984696652802771
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