Journal article
Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity
Mechanisms of ageing and development, Vol.131(2), pp.165-167
02/01/2010
DOI: 10.1016/j.mad.2009.12.009
PMCID: PMC2845985
PMID: 20064545
Abstract
Telomere length (TL), a measure of replicative senescence, decreases with aging, but the factors involved are incompletely understood. To determine if age-associated reductions in TL are related to habitual endurance exercise and maximal aerobic exercise capacity (maximal oxygen consumption, VO(2)max), we studied groups of young (18-32 years; n = 15,7 male) and older (55-72 years; n = 15,9 male) sedentary and young (n = 10,7 male) and older (n = 17,11 male) endurance exercise-trained healthy adults. Leukocyte TL (LTL) was shorter in the older (7059 +/- 141 bp) vs. young (8407 +/- 218) sedentary adults (P < 0.01). LTL of the older endurance-trained adults (7992 +/- 169 bp) was 900 bp greater than their sedentary peers (P < 0.01) and was not significantly different (P = 0.12) from young exercise-trained adults (8579 +/- 413). LTL was positively related to VO(2)max as a result of a significant association in older adults (r = 0.44, P < 0.01). Stepwise multiple regression analysis revealed that VO(2)max was the only independent predictor of LTL in the overall group. Our results indicate that LTL is preserved in healthy older adults who perform vigorous aerobic exercise and is positively related to maximal aerobic exercise capacity. This may represent a novel molecular mechanism underlying the "anti-aging" effects of maintaining high aerobic fitness. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Details
- Title: Subtitle
- Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity
- Creators
- Thomas J. LaRocca - University of Colorado BoulderDouglas R. Seals - University of Colorado BoulderGary L. Pierce - University of Colorado Boulder
- Resource Type
- Journal article
- Publication Details
- Mechanisms of ageing and development, Vol.131(2), pp.165-167
- DOI
- 10.1016/j.mad.2009.12.009
- PMID
- 20064545
- PMCID
- PMC2845985
- NLM abbreviation
- Mech Ageing Dev
- ISSN
- 0047-6374
- eISSN
- 1872-6216
- Publisher
- Elsevier
- Number of pages
- 3
- Grant note
- R01AG006537 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) M01RR000051 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) AG013038; AG006537; AG022241; AG015897; AG031141; AG000279; RR00051 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 02/01/2010
- Academic Unit
- Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984267139602771
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