Journal article
Leukotriene Receptor Antagonists in the Treatment of Allergic Rhinitis
The Annals of pharmacotherapy, Vol.35(10), pp.1274-1277
10/2001
DOI: 10.1345/aph.1A001
PMID: 11675859
Abstract
OBJECTIVE:
To review the literature examining the clinical use of leukotriene receptor antagonists in the treatment of allergic rhinitis.
DATA SOURCES:
Biomedical literature accessed through MEDLINE (1990–November 2000) and Current Contents (week 35 of 1999 to week 48 of 2000). Key terms included leukotriene antagonists, montelukast, zafirlukast, and rhinitis (allergic).
DATA SYNTHESIS:
Preliminary evidence on the clinical use of either montelukast or zafirlukast as monotherapy is equivocal, with one study noting benefit and another noting lack of benefit in symptom amelioration. A third study suggests that these agents may have a role in further modifying allergic rhinitis symptoms when used in combination with standard treatments.
CONCLUSIONS:
Future large-scale studies should assess the efficacy of these agents in the treatment of allergic rhinitis, in particular, to identify subsets of patients likely to derive the most benefit. Available data suggest it is reasonable and safe to add these agents to standard therapy if symptomatology remains unresolved.
Details
- Title: Subtitle
- Leukotriene Receptor Antagonists in the Treatment of Allergic Rhinitis
- Creators
- Michelle L Maynard - University of IowaMichael E Ernst - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The Annals of pharmacotherapy, Vol.35(10), pp.1274-1277
- Publisher
- SAGE Publications
- DOI
- 10.1345/aph.1A001
- PMID
- 11675859
- ISSN
- 1060-0280
- eISSN
- 1542-6270
- Language
- English
- Date published
- 10/2001
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984297444502771
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