Journal article
Levels of autonomy in synthetic biology engineering
Molecular systems biology, Vol.16(12), pp.e10019-n/a
12/2020
DOI: 10.15252/msb.202010019
PMCID: PMC7744957
PMID: 33331138
Abstract
Engineering biological organisms is a complex, challenging, and often slow process. Other engineering domains have addressed such challenges with a combination of standardization and automation, enabling a divide-and-conquer approach to complexity and greatly increasing productivity. For example, standardization and automation allow rapid and predictable translation of prototypes into fielded applications (e.g., "design for manufacturability"), simplify sharing and reuse of work between groups, and enable reliable outsourcing and integration of specialized subsystems. Although this approach has also been part of the vision of synthetic biology, almost since its very inception (Knight & Sussman, 1998), this vision still remains largely unrealized (Carbonell et al, 2019). Despite significant progress over the last two decades, which have for example allowed obtaining and editing DNA sequences in easier and cheaper ways, the full process of organism engineering is still typically rather slow, manual, and artisanal.
Details
- Title: Subtitle
- Levels of autonomy in synthetic biology engineering
- Creators
- Jacob Beal - RTXMiles Rogers - RTX
- Resource Type
- Journal article
- Publication Details
- Molecular systems biology, Vol.16(12), pp.e10019-n/a
- Publisher
- Wiley
- DOI
- 10.15252/msb.202010019
- PMID
- 33331138
- PMCID
- PMC7744957
- ISSN
- 1744-4292
- eISSN
- 1744-4292
- Number of pages
- 5
- Grant note
- 1522074 / NSF Expeditions in Computing Program Award as part of the Living Computing Project
- Language
- English
- Date published
- 12/2020
- Academic Unit
- Electrical and Computer Engineering
- Record Identifier
- 9984627238002771
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