Journal article
Levels of tin and organotin compounds in human urine samples from Iowa, United States
Journal of Environmental Science and Health, Part A, Vol.54(9), pp.884-890
07/29/2019
DOI: 10.1080/10934529.2019.1605779
PMCID: PMC6664795
PMID: 31057082
Abstract
Exposure to tin in the general US population is near ubiquitous, as determined using urinary tin levels measured by inductively coupled plasma mass spectrometry (ICP-MS). Urinary tin levels are associated with chronic health outcomes, such as diabetes; however, it is unclear if these associations are due to the presence of inorganic and organic forms of tin in urine. To address this knowledge gap, levels of total tin and several organotin compounds (OTCs) were measured in convenience urine samples from pregnant women and adults from Iowa, United States. Total tin and OTC levels in urine samples were quantified using ICP-MS and gas chromatography with pulsed flame photometric detection (GC-PFPD), respectively. ICP-MS detected tin in almost all urine samples from both study populations. Low levels of dibutyltin were detected in two out of fifty human urine samples. Importantly, storage of urine samples in plastic containers, but not HNO 3 -pretreated glass vials drastically reduced the recoveries of OTCs, in particular, tributyltin. Although their detection frequency is low, exposures to OTC should be considered when studying associations between human exposures to tin compounds and adverse health outcomes; however, urinary OTC levels measured in banked urine samples may not be suitable as biomarkers of OTC exposure.
Details
- Title: Subtitle
- Levels of tin and organotin compounds in human urine samples from Iowa, United States
- Creators
- Manuel Gadogbe - Department of Occupational & Environmental Health, College of Public Health, University of IowaWei Bao - Department of Epidemiology, College of Public Health, University of IowaBrian R Wels - State Hygienic Laboratory, University of IowaSuzie Y Dai - State Hygienic Laboratory, University of IowaDonna A Santillan - Department of Obstetrics and Gynecology, University of Iowa Roy J. and Lucille A. Carver College of MedicineMark K Santillan - Department of Obstetrics and Gynecology, University of Iowa Roy J. and Lucille A. Carver College of MedicineHans-Joachim Lehmler - Department of Occupational & Environmental Health, College of Public Health, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of Environmental Science and Health, Part A, Vol.54(9), pp.884-890
- DOI
- 10.1080/10934529.2019.1605779
- PMID
- 31057082
- PMCID
- PMC6664795
- NLM abbreviation
- J Environ Sci Health A Tox Hazard Subst Environ Eng
- ISSN
- 1093-4529
- eISSN
- 1532-4117
- Publisher
- Taylor & Francis
- Grant note
- P30 ES005605 / National Institute of Environmental Health Sciences/National Institutes of Health
- Language
- English
- Date published
- 07/29/2019
- Academic Unit
- Occupational and Environmental Health; Epidemiology; Iowa Neuroscience Institute; Obstetrics and Gynecology
- Record Identifier
- 9983930280902771
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