Journal article
Lifestyle and Anthropometric Risk Factors for Prostate Cancer in a Cohort of Iowa Men
Annals of epidemiology, Vol.10(6), pp.361-369
2000
DOI: 10.1016/S1047-2797(00)00057-0
PMID: 10964002
Abstract
PURPOSE: Several lines of evidence suggest that prostate cancer has a hormonal etiology. We evaluated factors known to modulate the endocrine system, including alcohol and tobacco use, physical activity, and obesity as risk factors for prostate cancer. METHODS: Cancer-free controls (n = 1572) who participated in a population-based case-control study from 1986-1989 (81% response rate) were followed through 1995 for cancer incidence by linkage to the Iowa Cancer Registry; 101 incident prostate cancers were identified. RESULTS: Compared with non-users of alcohol, men who consumed < 22 grams alcohol per week (relative risk [RR] = 1.1; 95% Confidence Interval [CI] 0.6- 2.1), 22-96 grams alcohol per week (RR = 2.6; 95% CI 1.4-4.6) and > 96 grams alcohol per week (RR = 3.1; 95% CI 1.5-6.3) were at increased risk of prostate cancer after adjustment for age, family history of prostate cancer, body mass index, total energy, and intake of carbohydrate, linoleic acid, lycopene, retinol, and red meat (p for trend < 0.0001). The respective RRs were similar when assessing type of alcohol consumed (beer, wine or liquor) or when well-differentiated, localized tumors were excluded. Body mass index was only weakly and positively associated with prostate cancer after adjustment for age (p for trend = 0.3), but this association strengthened after multivariate adjustment (p for trend = 0.08) and exclusion of well- differentiated, localized tumors (p for trend = 0.03). For the latter tumors, men with a BMI of 24.1-26.6 kg/m2 (RR = 1.5; 95% CI 0.7-3.0 and > 26.6 kg/m2 (RR = 2.1; 95% CI 1.1-4.3) were at elevated risk compared to men with a BMI < 24.1 kg/m2. Tobacco use (cigarettes, cigar/pipe, chewing tobacco and snuff use), height, weight, and both leisure and occupational physical activity were not associated with risk of prostate cancer in this cohort. CONCLUSIONS: These data suggest that in white men obesity is a risk factor for more clinically significant prostate cancer and confirm limited previous reports showing that alcohol consumption is positively associated with prostate cancer and that this risk is not limited to any specific type of alcohol.
Details
- Title: Subtitle
- Lifestyle and Anthropometric Risk Factors for Prostate Cancer in a Cohort of Iowa Men
- Creators
- Shannon D Putnam - Department of Preventive Medicine and Environment Health, University of Iowa, College of Medicine, Iowa City, IA USAJames R Cerhan - Department of Preventive Medicine and Environment Health, University of Iowa, College of Medicine, Iowa City, IA USAAlexander S Parker - University of IowaGregory D Bianchi - Department of Preventive Medicine and Environment Health, University of Iowa, College of Medicine, Iowa City, IA USARobert B Wallace - Department of Preventive Medicine and Environment Health, University of Iowa, College of Medicine, Iowa City, IA USAKenneth P Cantor - Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD USACharles F Lynch - Department of Preventive Medicine and Environment Health, University of Iowa, College of Medicine, Iowa City, IA USA
- Resource Type
- Journal article
- Publication Details
- Annals of epidemiology, Vol.10(6), pp.361-369
- DOI
- 10.1016/S1047-2797(00)00057-0
- PMID
- 10964002
- NLM abbreviation
- Ann Epidemiol
- ISSN
- 1047-2797
- eISSN
- 1873-2585
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2000
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9983995146402771
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