Journal article
Lifestyle-dependent brain change: a longitudinal cohort MRI study
Neurobiology of aging, Vol.69, pp.48-57
09/2018
DOI: 10.1016/j.neurobiolaging.2018.04.017
PMID: 29852410
Abstract
We investigated both independent and interconnected effects of 3 lifestyle factors on brain volume, measuring yearly changes using large-scale longitudinal magnetic resonance imaging, in middle-aged to older adults. We measured brain volumes in a cohort (n = 984, 49–79 years) from the Korean Genome and Epidemiology Study group, using baseline and follow-up estimates after 4 years. In our analysis, the accelerated brain atrophy in normal aging was observed across regions (e.g., brain tissue: -0.098 ± 0.01 mL/y, p < 0.001). An independent lifestyle-specific trend of brain atrophy across time was also evident in men, where smoking (p = 0.012) and physical activity (p = 0.014) showed the strongest association with the atrophy rate. Linear regression analysis of the interconnected effect revealed that brain atrophy is mitigated by intense physical activity in smoking males. Lifestyle factors did not show any significant effect on brain volume in women. These results provide important information regarding lifestyle factors that affect brain aging in mid-to-late adulthood. Our findings may aid in the identification of preventive measures against dementia.
Details
- Title: Subtitle
- Lifestyle-dependent brain change: a longitudinal cohort MRI study
- Creators
- Regina EY Kim - Korea UniversityChang-Ho Yun - Seoul National UniversityRobert J Thomas - Beth Israel Deaconess Medical CenterJang-Hoon Oh - Korea UniversityHans J Johnson - University of IowaSoriul Kim - Korea UniversitySeungku Lee - Korea UniversityHyung Suk Seo - Korea UniversityChol Shin - Korea University
- Resource Type
- Journal article
- Publication Details
- Neurobiology of aging, Vol.69, pp.48-57
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.neurobiolaging.2018.04.017
- PMID
- 29852410
- ISSN
- 0197-4580
- eISSN
- 1558-1497
- Grant note
- DOI: 10.13039/100000030, name: Centers for Disease Control and Prevention, award: 2011-E71004-00, 2012-E71005-00, 2013-E71005-00, 2014-E71003-00, 2015-P71001-00, 2016-E71003-00; DOI: 10.13039/100011273, name: ICT, award: 2012–0009830; DOI: 10.13039/100008893, name: University of Iowa
- Language
- English
- Date published
- 09/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Psychiatry
- Record Identifier
- 9984185465502771
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