Journal article
Lifetime Physical Activity and White Matter Hyperintensities in Cognitively Intact Adults
Nursing research (New York), Vol.68(3), pp.210-217
05/2019
DOI: 10.1097/NNR.0000000000000341
PMCID: PMC6715893
PMID: 30672910
Abstract
White matter hyperintensities (WMHs) observed on magnetic resonance images are associated with depression and increase the risk of stroke, dementia, and death. The association between physical activity and WMHs has been inconsistently reported in the literature, perhaps because studies did not account for a lifetime of physical activity or depression.\nThe aim of this study was to determine the extent to which a lifetime of leisure-time physical activity is associated with less WMHs while accounting for depression.\nFace-to-face interviews were conducted with the Lifetime Total Physical Activity Questionnaire, where the metabolic equivalent of task hours per week per year was calculated. Cognitively intact participants also underwent magnetic resonance imaging, where WMHs as a percentage of intracranial volume was obtained. Hierarchical multiple linear regression was performed to compare WMHs in a more active group with a group with no psychiatric history (n = 20, mean age = 62.2 years), with a less active group with no psychiatric history (n = 13, mean age = 64.0 years), and a less active group with history of late-onset depression (n = 14, mean age = 62.8 years).\nThere was not a statistically significant difference in WMHlg10 between the more and less active groups without a psychiatric history (b = .09, p > .05) or between the more active group without a psychiatric history and the less active group with a history of depression (b = .01, p > .05). The model was predictive of WMHlg10, explaining an adjusted 15% of the variance in WMHs (p = .041).\nA lifetime of leisure-time physical activity was not associated with WMHs when accounting for depression.
Details
- Title: Subtitle
- Lifetime Physical Activity and White Matter Hyperintensities in Cognitively Intact Adults
- Creators
- Elisa R Torres - Elisa R. Torres, PhD, RN, is Professor, University of Mississippi Medical Center School of Nursing, Jackson. At the time this data was collected, she was Associate Faculty, University of Iowa College of Nursing. Siobhan M. Hoscheidt, PhD, is Assistant Professor, Wake Forest School of Medicine, Winston-Salem, North Carolina. Barbara B. Bendlin, PhD, is Associate Professor, University of Wisconsin-Madison School of Medicine and Public Health. Vincent A. Magnotta, PhD, is Professor, University of Iowa College of Medicine. Gabriel D. Lancaster, MS, is Medical Student, University of Iowa College of Medicine. Roger L. Brown, PhD, is Professor, University of Wisconsin-Madison School of Nursing. Sergio Paradiso, MD, PhD, is Physician in Private Practice specializing in Psychiatry and Pyschotherapy, Catania, ItalySiobhan M HoscheidtBarbara B BendlinVincent A MagnottaGabriel D LancasterRoger L BrownSergio Paradiso
- Resource Type
- Journal article
- Publication Details
- Nursing research (New York), Vol.68(3), pp.210-217
- DOI
- 10.1097/NNR.0000000000000341
- PMID
- 30672910
- PMCID
- PMC6715893
- NLM abbreviation
- Nurs Res
- ISSN
- 0029-6562
- eISSN
- 1538-9847
- Publisher
- United States
- Grant note
- KL2 TR000428 / NCATS NIH HHS\nKL2 TR002374 / NCATS NIH HHS\nP30 AG049638 / NIA NIH HHS\nU54 GM115428 / NIGMS NIH HHS\nP50 AG033514 / NIA NIH HHS\nR01 AG037639 / NIA NIH HHS\nUL1 TR000427 / NCATS NIH HHS\nUL1 RR024979 / NCRR NIH HHS\nP30 AG062715 / NIA NIH HHS\nK23 AG027837 / NIA NIH HHS\nT32 NR007110 / NINR NIH HHS\nUL1 TR002373 / NCATS NIH HHS
- Language
- English
- Date published
- 05/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984066379402771
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