Journal article
Light Therapy for Cancer-Related Fatigue in (Non-)Hodgkin Lymphoma Survivors: Results of a Randomized Controlled Trial
Cancers, Vol.13(19), 4948
09/30/2021
DOI: 10.3390/cancers13194948
PMCID: PMC8508131
PMID: 34638428
Abstract
PURPOSETo evaluate the short- and long-term effects of light therapy on fatigue (primary outcome) and sleep quality, depression, anxiety, quality of life, and circadian rhythms (secondary outcomes) in survivors of (non-)Hodgkin lymphoma presenting with chronic cancer-related fatigue. METHODSWe randomly assigned 166 survivors (mean survival 13 years) to a bright white light intervention (BWL) or dim white light comparison (DWL) group. Measurements were completed at baseline (T0), post-intervention (T1), at three (T2), and nine (T3) months follow-up. A mixed-effect modeling approach was used to compare linear and non-linear effects of time between groups. RESULTSThere were no significant differences between BWL and DWL in the reduction in fatigue over time. Both BWL and DWL significantly (p < 0.001) improved fatigue levels during the intervention followed by a slight reduction in this effect during follow-up (EST0-T1 = -0.71; EST1-T3 = 0.15). Similar results were found for depression, sleep quality, and some aspects of quality of life. Light therapy had no effect on circadian rhythms. CONCLUSIONSBWL was not superior in reducing fatigue compared to DWL in HL and DLBCL survivors. Remarkably, the total sample showed clinically relevant and persistent improvements on fatigue not commonly seen in longitudinal observational studies in these survivors.
Details
- Title: Subtitle
- Light Therapy for Cancer-Related Fatigue in (Non-)Hodgkin Lymphoma Survivors: Results of a Randomized Controlled Trial
- Creators
- Daniëlle E. J Starreveld - The Netherlands Cancer InstituteLaurien A Daniels - University Medical CenterJacobien M Kieffer - The Netherlands Cancer InstituteHeiddis B Valdimarsdottir - Department of Oncological Sciences, Mount Sinai School of MedicineJessie de Geus - The Netherlands Cancer InstituteMirthe Lanfermeijer - The Netherlands Cancer InstituteEus J. W van Someren - University Medical CenterG. Esther A Habers - Leiden UniversityJos A Bosch - University of AmsterdamCécile P. M Janus - Erasmus MCDick Johan van Spronsen - University Medical CenterRoel J de Weijer - University Medical CenterErik W. A Marijt - Leiden University Medical CenterEva de Jongh - Albert Schweitzer HospitalJosée M Zijlstra - Department of Hematology, Amsterdam University Medical Centers, Cancer Center AmsterdamLara H Böhmer - Department of Hematology, Haga Teaching HospitalMargreet Houmes - Department of Hematology, Admiraal de Ruyter HospitalMarie José Kersten - Department of Hematology, Amsterdam University Medical Centers, Cancer Center AmsterdamCatharina M Korse - The Netherlands Cancer InstituteHuub H van Rossum - The Netherlands Cancer InstituteWilliam H Redd - Department of Oncological Sciences, Mount Sinai School of MedicineSusan K Lutgendorf - University of IowaSonia Ancoli-israel - Department of Psychiatry, University of CaliforniaFlora E van Leeuwen - The Netherlands Cancer InstituteEveline M. A Bleiker - Leiden University Medical Center
- Resource Type
- Journal article
- Publication Details
- Cancers, Vol.13(19), 4948
- DOI
- 10.3390/cancers13194948
- PMID
- 34638428
- PMCID
- PMC8508131
- NLM abbreviation
- Cancers (Basel)
- ISSN
- 2072-6694
- eISSN
- 2072-6694
- Grant note
- DOI: 10.13039/501100004622, name: KWF Kankerbestrijding, award: NKI 2015-7909
- Language
- English
- Date published
- 09/30/2021
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984185481602771
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