Journal article
Light aversion in mice depends on nonimage-forming irradiance detection
Behavioral neuroscience, Vol.124(6), pp.821-827
12/2010
DOI: 10.1037/a0021568
PMCID: PMC3313681
PMID: 21038932
Abstract
Detection of light in the eye underlies image-forming vision, but also regulates adaptive responses in physiology and behavior. Typically these adaptive responses do not involve image-forming vision, but depend on a relatively absolute measure of brightness (nonimage-forming irradiance detection). The goal of this study was to further understand how image-forming vision and nonimage-forming irradiance detection contribute to the effects of light on behavior. Three light dependent behaviors were assessed in wild-type, Rpe65-/- and rd1 mice. In Rpe65-/- mice, nonimage-forming irradiance detection is severely attenuated, but rod based visual acuity is relatively preserved. In rd1 mice visual acuity is nonrecordable, but nonimage-forming responses are less severely attenuated than Rpe65-/-. Positive masking, an image-forming vision dependent increase in wheel running, was absent in rd1 and restricted to higher irradiances in Rpe65-/-. Negative masking, a suppression of wheel running sensitivity with nonimage-forming irradiance detection input, was increased in rd1, but reduced in Rpe65-/- mice. By contrast, light aversion, an avoidance of brightly lit areas, was abolished in both Rpe65-/- and rd1. This shows that image-forming vision is not sufficient for light aversion, suggesting nonimage-forming irradiance detection motivates this behavior. Further, the differing effects of disease suggest that negative masking and light aversion are distinct responses with specialized nonimage-forming irradiance detection pathways.
Details
- Title: Subtitle
- Light aversion in mice depends on nonimage-forming irradiance detection
- Creators
- Stewart Thompson - Department of Ophthalmology and Visual Sciences and The Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USAAna RecoberTimothy W VogelAdisa KuburasJessica A OwensVal C SheffieldAndrew F RussoEdwin M Stone
- Resource Type
- Journal article
- Publication Details
- Behavioral neuroscience, Vol.124(6), pp.821-827
- DOI
- 10.1037/a0021568
- PMID
- 21038932
- PMCID
- PMC3313681
- NLM abbreviation
- Behav Neurosci
- ISSN
- 0735-7044
- eISSN
- 1939-0084
- Publisher
- United States
- Grant note
- R01 DE016511 / NIDCR NIH HHS Howard Hughes Medical Institute R01 DE016511-13A1 / NIDCR NIH HHS R01 DE016511-17 / NIDCR NIH HHS K08 NS066087 / NINDS NIH HHS R01 EY017168 / NEI NIH HHS
- Language
- English
- Date published
- 12/2010
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Medical Genetics and Genomics; Craniofacial Anomalies Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980092802771
Metrics
28 Record Views