Journal article
Light-dependent compartmentalization of transducin in rod photoreceptors
Molecular neurobiology, Vol.37(1), pp.44-51
02/2008
DOI: 10.1007/s12035-008-8015-2
PMID: 18425604
Abstract
Three major visual signaling proteins, transducin, arrestin, and recoverin undergo bidirectional translocations between the outer segment and inner compartments of rod photoreceptors in a light-dependent manner. The light-dependent translocation of proteins is believed to contribute to adaptation and neuroprotection of photoreceptor cells. The potential physiological significance and mechanisms of light-controlled protein translocations are at the center of current discussion. In this paper, I outline the latest advances in understanding the mechanisms of bidirectional translocation of transducin and determinants of its steady-state distribution in dark- and light-adapted photoreceptor cells.
Details
- Title: Subtitle
- Light-dependent compartmentalization of transducin in rod photoreceptors
- Creators
- Nikolai O Artemyev - Department of Molecular Physiology and Biophysics, University of Iowa College of Medicine, 5-532 Bowen Science Building, 51 Newton Road, Iowa, IA 52242, USA. nikolai-artemyev@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Molecular neurobiology, Vol.37(1), pp.44-51
- Publisher
- United States
- DOI
- 10.1007/s12035-008-8015-2
- PMID
- 18425604
- ISSN
- 0893-7648
- eISSN
- 1559-1182
- Grant note
- R01 EY-12682 / NEI NIH HHS R01 EY012682 / NEI NIH HHS
- Language
- English
- Date published
- 02/2008
- Academic Unit
- Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9984070582802771
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