Journal article
Limitations of EBV-PCR monitoring to detect EBV associated post-transplant lymphoproliferative disorder
Pediatric transplantation, Vol.7(3), pp.223-227
Accepted for publication 4 March 2003
06/2003
DOI: 10.1034/j.1399-3046.2003.00080.x
PMID: 12756048
Abstract
Post-transplant lymphoproliferative disorder (PTLD) represents a significant threat to the survival of pediatric transplant recipients. Epstein-Barr (EBV) viral load monitoring using polymerase chain reaction (PCR) has been reported to have a variable sensitively with relatively higher specificity as in an indicator of the development of PTLD. We report two cases of pathologically confirmed PTLD in children who failed to develop sustained increases in their EBV-PCR determined viral loads. We suggest that clinicians should be aware of the potential for false-negative results of EBV-PCR in pediatric transplant recipients.
Details
- Title: Subtitle
- Limitations of EBV-PCR monitoring to detect EBV associated post-transplant lymphoproliferative disorder
- Creators
- David A. Axelrod - Departments of Surgery andRonald Holmes - University of MichiganSusan E. Thomas - University of MichiganJohn C. Magee - Departments of Surgery and
- Resource Type
- Journal article
- Publication Details
- Pediatric transplantation, Vol.7(3), pp.223-227
- Edition
- Accepted for publication 4 March 2003
- DOI
- 10.1034/j.1399-3046.2003.00080.x
- PMID
- 12756048
- NLM abbreviation
- Pediatr Transplant
- ISSN
- 1397-3142
- eISSN
- 1399-3046
- Publisher
- Munksgaard International Publishers
- Number of pages
- 5
- Language
- English
- Date published
- 06/2003
- Academic Unit
- Surgery
- Record Identifier
- 9984322802402771
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