Journal article
Limitations of preoperative cytology for medullary thyroid cancer: Proposal for improved preoperative diagnosis for optimal initial medullary thyroid carcinoma specific surgery
Head & neck, Vol.43(3), pp.920-927
03/01/2021
DOI: 10.1002/hed.26550
PMID: 33269526
Abstract
Background Preoperative diagnosis of medullary thyroid carcinoma (MTC) is often difficult, given the poor sensitivity of fine-needle aspiration (FNA) cytology for MTC. This study investigates this issue and presents recommendations for improving preoperative diagnostic paradigms in MTC cases.
Design/Method Histopathologically confirmed MTC patients with preoperative cytologic assessment of index nodules were enrolled. FNA diagnosis, final pathology, and surgery details were collected.
Results Out of 71 patients, 49 (69%) were diagnosed by FNA as either definitive MTC (35, 49%) or suspected MTC (14, 20%) and 22 (31%) patients had no indication of MTC on FNA.
Conclusion In a tertiary-care setting, one-third of subjects had an FNA interpretation that did not suggest the possibility of MTC. The limitations of preoperative diagnosis are especially problematic for MTC as they can cause delayed or incomplete treatment. Additional testing is proposed to improve preoperative diagnosis and surgical care of MTC patients.
Details
- Title: Subtitle
- Limitations of preoperative cytology for medullary thyroid cancer: Proposal for improved preoperative diagnosis for optimal initial medullary thyroid carcinoma specific surgery
- Creators
- Alan D. Workman - Massachusetts Eye and Ear InfirmarySelen Soylu - Massachusetts Eye and Ear InfirmaryDipti Kamani - Massachusetts Eye and Ear InfirmaryAnahita Nourmahnad - Harvard UniversityNatalia Kyriazidis - Massachusetts Eye and Ear InfirmaryRyan Saade - Massachusetts Eye and Ear InfirmaryYin Ren - Massachusetts Eye and Ear InfirmaryLori Wirth - Massachusetts General HospitalWilliam C. Faquin - Massachusetts General HospitalAyse M. Onenerk - Haydarpaşa Numune Eğitim ve Araştırma HastanesiYuri E. Nikiforov - University of Pittsburgh Medical CenterZaid Al-Qurayshi - Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USAEmad Kandil - Tulane UniversityRichard T. Kloos - VeracyteLeslie Eldeiry - Harvard Vanguard Medical AssociatesCarrie Lubitz - Massachusetts General HospitalNikolaos Stathatos - Massachusetts General HospitalGregory W. Randolph - Massachusetts Eye and Ear Infirmary
- Resource Type
- Journal article
- Publication Details
- Head & neck, Vol.43(3), pp.920-927
- Publisher
- Wiley
- DOI
- 10.1002/hed.26550
- PMID
- 33269526
- ISSN
- 1043-3074
- eISSN
- 1097-0347
- Number of pages
- 8
- Grant note
- Ruane Thyroid Research Fund
- Language
- English
- Date published
- 03/01/2021
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984702819902771
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