Journal article
Limitations of recognition of modified-self by alloantigen-activated cytotoxic T lymphocytes
The Journal of immunology (1950), Vol.127(4), pp.1589-1591
10/1981
DOI: 10.4049/jimmunol.127.4.1589
PMID: 6168697
Abstract
Alloantigen-activated CTL from CBA (H-2k), but not from C57BL/6 (H-2b), mice were able to lyse autologous cells modified by incubation with TNP-HSA. Moreover, allogeneic CTL of the H-2k haplotype lysed syngeneic cells modified with high or low concentrations of TNBS. Allogeneic CTL of the H-2b haplotype, however, did not lyse autologous cells modified with low concentrations of TNBS, even though they lysed syngeneic cells modified with high concentrations of TNBS. These limitations of recognition by the different H-2 haplotypes paralleled the restrictions evident for MHC-restricted, TNBS-specific CTL. It was thus apparent that alloantigen-activated CTL are governed by the same limitations of recognition operant for the MHC-restricted, TNBS-specific CTL.
Details
- Title: Subtitle
- Limitations of recognition of modified-self by alloantigen-activated cytotoxic T lymphocytes
- Creators
- Zuhair K Ballas
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.127(4), pp.1589-1591
- DOI
- 10.4049/jimmunol.127.4.1589
- PMID
- 6168697
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Language
- English
- Date published
- 10/1981
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094755702771
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