Journal article
Limited numbers of recycling vesicles in small CNS nerve terminals: implications for neural signaling and vesicular cycling
Trends in neurosciences (Regular ed.), Vol.24(11), pp.637-643
2001
DOI: 10.1016/S0166-2236(00)02030-0
PMID: 11672807
Abstract
The tiny nerve terminals of central synapses contain far fewer vesicles than preparations commonly used for analysis of neurosecretion. Photoconversion of vesicles rendered fluorescent with the dye FM1-43 directly identified vesicles capable of engaging in exo–endocytotic recycling following stimulated Ca
2+ entry. This recycling pool typically contained 30–45 vesicles, only a minority fraction (15–20% on average) of the total vesicle population. The smallness of the recycling pool would severely constrain rates of quantal neurotransmission if classical pathways were solely responsible for vesicle recycling. Fortunately, vesicles can undergo rapid retrieval and reuse in addition to conventional slow recycling, to the benefit of synaptic information flow and neuronal signaling.
Details
- Title: Subtitle
- Limited numbers of recycling vesicles in small CNS nerve terminals: implications for neural signaling and vesicular cycling
- Creators
- Nobutoshi Harata - Dept of Molecular and Cellular Physiology, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305-5345, USAJason L Pyle - Dept of Molecular and Cellular Physiology, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305-5345, USAAlexander M Aravanis - Dept of Molecular and Cellular Physiology, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305-5345, USAMarina Mozhayeva - Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USAEge T Kavalali - Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USARichard W Tsien - Dept of Molecular and Cellular Physiology, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305-5345, USA
- Resource Type
- Journal article
- Publication Details
- Trends in neurosciences (Regular ed.), Vol.24(11), pp.637-643
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0166-2236(00)02030-0
- PMID
- 11672807
- ISSN
- 0166-2236
- eISSN
- 1878-108X
- Language
- English
- Date published
- 2001
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984025589002771
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