Journal article
Link Between Change in Cognition and Left Ventricular Function Following Cardiac Resynchronization Therapy
Journal of cardiopulmonary rehabilitation and prevention, Vol.30(6), pp.401-408
11/2010
DOI: 10.1097/HCR.0b013e3181e1739a
PMCID: PMC2978265
PMID: 20562712
Abstract
PURPOSEIn patients with heart failure, reduced cardiac ejection fraction has been associated with impaired cognition. Improving cardiac function may have beneficial effects on cognition; however, no controlled intervention studies have examined this possibility. Cardiac resynchronization therapy (CRT) is one intervention that has been shown to increase cardiac function. The goals of the current study were to (1) evaluate neuropsychological performance before and 3 months after crt and (2) examine follow-up neuropsychological performance of patients classified on the basis of extent of improved left ventricular ejection fraction (LVEF).
METHODS:Twenty-seven patients with moderate to severe heart failure completed a neuropsychological assessment, 6-minute walk test, and transthoracic echocardiography before and 3 months after CRT. Patients were classified on the basis of improvement in LVEF. Results of a multivariate analysis of variance revealed a significant effect of improvement in LVEF on change in cognition (Wilks Λ, P = .031).
RESULTS:Patients with improved LVEF demonstrated significant increases on measures of executive functioning (F = 8.57, P = .007) and visuospatial function (F = 7.52, P = .011) and less decline on global cognition (F = 5.73, P = .024) than those without LVEF improvement.
CONCLUSIONS:Findings provide preliminary evidence that improved LVEF in response to CRT is associated with enhanced cognitive outcomes within 3 months of CRT. Patients with improved LVEF showed better outcomes on measures of executive functioning, global cognition, and visuospatial functioning. Future, controlled, large-scale trials will be necessary to determine whether there is an underlying causal relationship linking increase in LVEF and cognition.
Details
- Title: Subtitle
- Link Between Change in Cognition and Left Ventricular Function Following Cardiac Resynchronization Therapy
- Creators
- Karin Hoth - Department of Medicine, National Jewish Health, and Departments of Psychiatry and Neurology, University of Colorado Denver (Dr Hoth); Departments of Psychiatry and Human Behavior (Drs Hoth and Cohen) and Cardiology (Dr Poppas, Ellison, and Cho and Mr Sokobin), Warren Alpert Medical School of Brown University, Providence, Rhode Island; and Department of Psychology, Behavioral Neuroscience, University of Missouri– St Louis (Dr Paul)Athena PoppasKristin EllisonRobert PaulAndrew SokobinYoungsoo ChoRonald Cohen
- Resource Type
- Journal article
- Publication Details
- Journal of cardiopulmonary rehabilitation and prevention, Vol.30(6), pp.401-408
- DOI
- 10.1097/HCR.0b013e3181e1739a
- PMID
- 20562712
- PMCID
- PMC2978265
- NLM abbreviation
- J Cardiopulm Rehabil Prev
- ISSN
- 1932-7501
- eISSN
- 1932-751X
- Publisher
- Lippincott Williams & Wilkins, Inc
- Language
- English
- Date published
- 11/2010
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003924202771
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