Journal article
Linkage analyses of IQ in the collaborative study on the genetics of alcoholism (COGA) sample
Behavior genetics, Vol.36(1), pp.77-86
01/2006
DOI: 10.1007/s10519-005-9009-8
PMID: 16341907
Abstract
Intelligence, as measured by standardized psychological tests, has been shown to be highly heritable, though identifying specific genes influencing general intelligence has proven difficult. We conducted genome-wide linkage analyses to identify chromosomal regions containing genes influencing intelligence, as measured by WAIS full-scale IQ (FSIQ), performance IQ (PIQ) and verbal IQ (VIQ). Non-parametric multipoint linkage analyses were conducted with Merlin-regress software, using a sample of 1,111 genotyped and phenotyped individuals from 201 families, ascertained as part of the Collaborative Study on the Genetics of Alcoholism (COGA). The strongest evidence of linkage was obtained for FSIQ on chromosome 6 (LOD=3.28, 12 cM) near the marker D6S1006. This region was also implicated with suggestive linkage in a recently published genome screen of IQ in Australian and Dutch twin pairs, and it has been implicated in linkage studies of developmental dyslexia. Our findings provide further support that chromosome 6p contains gene(s) affecting intelligence.
Details
- Title: Subtitle
- Linkage analyses of IQ in the collaborative study on the genetics of alcoholism (COGA) sample
- Creators
- Danielle M Dick - Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA. dickd@psychiatry.wustl.eduFazil AlievLaura BierutAlison GoateJohn RiceAnthony HinrichsSarah BertelsenJen C WangGerald DunnSam KupermanMarc SchuckitJohn Nurnberger JrBernice PorjeszHenri BeglieterJohn KramerVictor Hesselbrock
- Resource Type
- Journal article
- Publication Details
- Behavior genetics, Vol.36(1), pp.77-86
- Publisher
- United States
- DOI
- 10.1007/s10519-005-9009-8
- PMID
- 16341907
- ISSN
- 0001-8244
- eISSN
- 1573-3297
- Grant note
- M01-RR06192 / NCRR NIH HHS U10AA08401 / NIAAA NIH HHS
- Language
- English
- Date published
- 01/2006
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984004197802771
Metrics
16 Record Views