Journal article
Linkage analysis of neurofibromatosis type I, using chromosome 17 DNA markers
American journal of human genetics, Vol.44(1), pp.48-50
01/1989
PMCID: PMC1715469
PMID: 2491782
Abstract
The gene for von Recklinghausen neurofibromatosis type 1 (NF1) has recently been mapped to the pericentromeric region of human chromosome 17. To further localize the NF1 gene, linkage analysis using chromosome 17 DNA markers was performed on 11 multigeneration families with 175 individuals, 57 of whom were affected. The markers used were D17Z1 (p17H8), D17S58 (EW301), D17S54 (EW203), D17S57 (EW206), D17S73 (EW207), CRI-L946, HOX-2, and growth hormone. Tight linkage was found between NF1 and D17Z1, D17S58, and D17S57 with a recombination fraction of zero. One recombinant was detected between NF1 and D17S73, showing linkage with a 10% recombination fraction. No linkage was detected between NF1 and CRI-L946 or between HOX-2 and growth hormone. Our data are consistent with the proposed gene order pter D17S58-D17Z1-NF1-D17S57-D17S73 qter.
Details
- Title: Subtitle
- Linkage analysis of neurofibromatosis type I, using chromosome 17 DNA markers
- Creators
- S D Kittur - National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224M M Bagdon - National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224M L Lubs - National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224J A Phillips - National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224J C Murray - National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224S A Slaugenhaupt - National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224A Chakravarti - National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224W H Adler - National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224
- Resource Type
- Journal article
- Publication Details
- American journal of human genetics, Vol.44(1), pp.48-50
- PMID
- 2491782
- PMCID
- PMC1715469
- NLM abbreviation
- Am J Hum Genet
- ISSN
- 0002-9297
- eISSN
- 1537-6605
- Language
- English
- Date published
- 01/1989
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025676002771
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