Journal article
Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes
Biological psychology, Vol.61(1), pp.229-248
2002
DOI: 10.1016/S0301-0511(02)00060-1
PMID: 12385677
Abstract
Linkage analyses of highly heritable electrophysiological phenotypes (EEG, ERP) that can potentially identify individuals at risk for alcoholism were performed on a large sample of families with a high density of alcohol dependence as part of the Collaborative Study on the Genetics of Alcoholism (COGA); these genetic findings are summarized. Quantitative trait loci (QTLs) were identified for several ERP characteristics (P300, N100, N400) and for the beta frequencies of the EEG where we report linkage and linkage disequilibrium at a GABA
A receptor gene on chromosome 4. Genetic analyses of ERPs suggest that several regions of the human genome contain genetic loci related to the generation of N100, N400 and P300, which are possible candidate loci underlying the functional organization of human neuroelectric activity. The advent of genomics and proteomics and a fuller understanding of gene regulation, will open new horizons on the critical electrical events so essential for human brain function.
Details
- Title: Subtitle
- Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes
- Creators
- Bernice Porjesz - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, Box 1203, HSCB, 450 Clarkson Avenue, Brooklyn, NY 11203-2098, USAHenri Begleiter - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, Box 1203, HSCB, 450 Clarkson Avenue, Brooklyn, NY 11203-2098, USAKongming Wang - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, Box 1203, HSCB, 450 Clarkson Avenue, Brooklyn, NY 11203-2098, USALaura Almasy - Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USADavid B Chorlian - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, Box 1203, HSCB, 450 Clarkson Avenue, Brooklyn, NY 11203-2098, USAArthur T Stimus - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, Box 1203, HSCB, 450 Clarkson Avenue, Brooklyn, NY 11203-2098, USASamuel Kuperman - University of Iowa, Psychiatry Research, Iowa City, IA 52242, USASean J O'Connor - Indiana University School of Medicine, Indianapolis, IN 46202, USAJohn Rohrbaugh - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USALance O Bauer - Department of Psychiatry, University of Connecticut Health Center, Farmington, CT 06030, USAHoward J Edenberg - Indiana University School of Medicine, Indianapolis, IN 46202, USAAlison Goate - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USAJohn P Rice - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USATheodore Reich - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
- Resource Type
- Journal article
- Publication Details
- Biological psychology, Vol.61(1), pp.229-248
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0301-0511(02)00060-1
- PMID
- 12385677
- ISSN
- 0301-0511
- eISSN
- 1873-6246
- Language
- English
- Date published
- 2002
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003417402771
Metrics
22 Record Views