Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus

Bernice Porjesz; Laura Almasy; Howard J Edenberg; Kongming Wang; David B Chorlian; Tatiana Foroud; Alison Goate; John P Rice; Sean J O'Connor; John Rohrbaugh; Samuel Kuperman; Lance O Bauer; Raymond R Crowe; Marc A Schuckit; Victor Hesselbrock; P. Michael Conneally; Jay A Tischfield; Ting-Kai Li; Theodore Reich; Henri Begleiter

doi:10.1073/pnas.052716399

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Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus

Journal article

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Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus

Bernice Porjesz, Laura Almasy, Howard J Edenberg, Kongming Wang, David B Chorlian, Tatiana Foroud, Alison Goate, John P Rice, Sean J O'Connor, John Rohrbaugh, …

Proceedings of the National Academy of Sciences - PNAS, Vol.99(6), pp.3729-3733

03/19/2002

DOI: 10.1073/pnas.052716399

PMCID: PMC122592

PMID: 11891318

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Abstract

Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13–28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by γ-aminobutyric acid type A (GABA A ) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABA A receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.

Biological Sciences

Details

Title: Subtitle: Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus
Creators: Bernice Porjesz
Laura Almasy
Howard J Edenberg
Kongming Wang
David B Chorlian
Tatiana Foroud
Alison Goate
John P Rice
Sean J O'Connor
John Rohrbaugh
Samuel Kuperman
Lance O Bauer
Raymond R Crowe
Marc A Schuckit
Victor Hesselbrock
P. Michael Conneally
Jay A Tischfield - Department of Genetics, Rutgers University, Nelson Biological Laboratories, Piscataway, NJ 08854
Ting-Kai Li
Theodore Reich
Henri Begleiter - Department of Genetics, Rutgers University, Nelson Biological Laboratories, Piscataway, NJ 08854
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.99(6), pp.3729-3733
DOI: 10.1073/pnas.052716399
PMID: 11891318
PMCID: PMC122592
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 03/19/2002
Academic Unit: Psychiatry; Stead Family Department of Pediatrics
Record Identifier: 9984003465902771

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