Journal article
Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26-6q27
American journal of human genetics, Vol.40(4), pp.338-350
04/1987
PMCID: PMC1684087
PMID: 2883890
Abstract
Linkage disequilibrium was observed between newly identified DNA polymorphisms and a previously described protein polymorphism for plasminogen. This finding implies that the two types of polymorphisms describe variation at the same locus. The plasminogen gene was mapped to chromosomal bands 6q26-q27 using somatic-cell hybrids and in situ hybridization. Linkage disequilibrium between protein and DNA polymorphisms has utility in substituting for protein typing in instances where only DNA samples are available, such as from deceased individuals or extinct species. The technique may be useful when cross-hybridizing sequences make the interpretation of Southern blot patterns difficult and may obviate the need for extensive DNA sequencing. In some cases, disequilibrium may provide information useful for determining the appropriate direction for chromosome walks from a marker locus to a target locus.
Details
- Title: Subtitle
- Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26-6q27
- Creators
- Jeffrey C MurrayKenneth H BuetowMark DonovanSigrid HornungArno G MotulskyChristine DistecheKaren DyerKaren SwisshelmJean AndersonEloise GiblettEvan SadlerRoger EddyThomas B Shows
- Resource Type
- Journal article
- Publication Details
- American journal of human genetics, Vol.40(4), pp.338-350
- PMID
- 2883890
- PMCID
- PMC1684087
- NLM abbreviation
- Am J Hum Genet
- ISSN
- 0002-9297
- eISSN
- 1537-6605
- Language
- English
- Date published
- 04/1987
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025318402771
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