Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample

Arpana Agrawal; Anthony L Hinrichs; Gerald Dunn; Sarah Bertelsen; Danielle M Dick; Scott F Saccone; Nancy L Saccone; Richard A Grucza; Jen C Wang; C. Robert Cloninger; Howard J Edenberg; Tatiana Foroud; Victor Hesselbrock; John Kramer; Kathleen K Bucholz; Samuel Kuperman; John I Nurnberger; Bernice Porjesz; Marc A Schuckit; Alison M Goate; Laura J Bierut

doi:10.1016/j.drugalcdep.2007.08.015

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Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample

Journal article

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Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample

Arpana Agrawal, Anthony L Hinrichs, Gerald Dunn, Sarah Bertelsen, Danielle M Dick, Scott F Saccone, Nancy L Saccone, Richard A Grucza, Jen C Wang, C. Robert Cloninger, …

Drug and alcohol dependence, Vol.93(1), pp.12-20

2008

DOI: 10.1016/j.drugalcdep.2007.08.015

PMCID: PMC2266629

PMID: 17942244

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Abstract

Dependence on alcohol and illicit drugs frequently co-occur. Results from a number of twin studies suggest that heritable influences on alcohol dependence and drug dependence may substantially overlap. Using large, genetically informative pedigrees from the Collaborative Study on the Genetics of Alcoholism (COGA), we performed quantitative linkage analyses using a panel of 1717 SNPs. Genome-wide linkage analyses were conducted for quantitative measures of DSM-IV alcohol dependence criteria, cannabis dependence criteria and dependence criteria across any illicit drug (including cannabis) individually and in combination as an average score across alcohol and illicit drug dependence criteria. For alcohol dependence, LOD scores exceeding 2.0 were noted on chromosome 1 (2.0 at 213 cM), 2 (3.4 at 234 cM) and 10 (3.7 at 60 cM). For cannabis dependence, a maximum LOD of 1.9 was noted at 95 cM on chromosome 14. For any illicit drug dependence, LODs of 2.0 and 2.4 were observed on chromosome 10 (116 cM) and 13 (64 cM) respectively. Finally, the combined alcohol and/or drug dependence symptoms yielded LODs >2.0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence.

Illicit drugs

Alcohol

COGA

Cannabis

Linkage

Dependence

Details

Title: Subtitle: Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
Creators: Arpana Agrawal - Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, United States
Anthony L Hinrichs - Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, United States
Gerald Dunn - Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, United States
Sarah Bertelsen - Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, United States
Danielle M Dick - Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, United States
Scott F Saccone - Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, United States
Nancy L Saccone - Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, United States
Richard A Grucza - Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, United States
Jen C Wang - Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, United States
C. Robert Cloninger - Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, United States
Howard J Edenberg - Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, United States
Tatiana Foroud - Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, United States
Victor Hesselbrock - University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, United States
John Kramer - University of Iowa College of Medicine, Iowa City, IA 52242, United States
Kathleen K Bucholz - Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, United States
Samuel Kuperman - University of Iowa Hospitals, Iowa City, IA 52242, United States
John I Nurnberger - Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, United States
Bernice Porjesz - SUNY Health Science Center at Brooklyn, 450 Clarkson Avenue, Brooklyn, NY 11203, United States
Marc A Schuckit - University of California at San Diego, 3350 La Jolla Villa Drive, San Diego, CA 92093, United States
Alison M Goate - Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, United States
Laura J Bierut - Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, United States
Resource Type: Journal article
Publication Details: Drug and alcohol dependence, Vol.93(1), pp.12-20
DOI: 10.1016/j.drugalcdep.2007.08.015
PMID: 17942244
PMCID: PMC2266629
NLM abbreviation: Drug Alcohol Depend
ISSN: 0376-8716
eISSN: 1879-0046
Publisher: Elsevier Ireland Ltd
Language: English
Date published: 2008
Academic Unit: Psychiatry; Stead Family Department of Pediatrics
Record Identifier: 9984004188502771

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