Journal article
Linking clinical variables to health-related quality of life in Parkinson's disease
Parkinsonism & related disorders, Vol.8(3), pp.199-209
2002
DOI: 10.1016/S1353-8020(01)00044-X
PMID: 12039432
Abstract
Objective: Identify the point-in-time relationship between Parkinson's disease (PD) signs and symptoms and measures of health-related quality of life (HRQL).
Background: Clinical measures used in PD assessments traditionally emphasize physical signs and symptoms. We hypothesized that these measures would be strongly associated with the physical function dimensions of HRQL that reflect mental symptoms.
Design/methods: A cross-sectional study of 193 neurology clinic PD patients employed self-administered in-clinic and take-home questionnaires and in-person clinical examinations and interviews.
Results: The variance explained by PD physical signs and symptoms was substantial for physical function, but only modest for all other HRQL dimensions. Mental symptoms explained a larger proportion of variance than physical symptoms for 12 of the 14 HRQL measures.
Conclusion: PD patients’ well-being, general health perceptions, health satisfaction and overall HRQL are strongly influenced by mental health symptoms and more weakly influenced by physical symptoms. Clinical evaluation of PD patients should include mental health and self-reported HRQL assessment.
Details
- Title: Subtitle
- Linking clinical variables to health-related quality of life in Parkinson's disease
- Creators
- Elizabeth A Chrischilles - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA 52242, USALinda M Rubenstein - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA 52242, USAMargaret D Voelker - Department of Internal Medicine, College of Medicine, The University of Iowa, Iowa City, IA 52242, USARobert B Wallace - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA 52242, USARobert L Rodnitzky - Department of Neurology, College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Parkinsonism & related disorders, Vol.8(3), pp.199-209
- DOI
- 10.1016/S1353-8020(01)00044-X
- PMID
- 12039432
- NLM abbreviation
- Parkinsonism Relat Disord
- ISSN
- 1353-8020
- eISSN
- 1873-5126
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2002
- Academic Unit
- Neurology; Pharmacy; Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9983995140802771
Metrics
21 Record Views