Journal article
Lipid Nanoparticle Development in Practice: Challenges and Collective Insights
Pharmaceutical research, Vol.43(2), pp.311-319
02/2026
DOI: 10.1007/s11095-026-04025-3
PMID: 41572106
Abstract
Lipid nanoparticles (LNPs) have emerged as a versatile delivery platform for improving pharmacokinetic performance, protecting nucleic acid cargo, and enabling tissue- and cell-specific targeting. Continued advancement of LNP-based therapeutics requires a deeper understanding of how raw material quality, formulation parameters, nanoparticle architecture, and biological context collectively influence clinical performance. In this Perspective, we discuss key challenges, practical insights, and lessons learned from ongoing LNP development efforts, with emphasis on characterization strategies, delivery specificity, scale-up considerations, long-term stability, and emerging applications of artificial intelligence. We highlight the importance of rational design principles, robust and reproducible manufacturing practices, comprehensive analytical characterization, and innovative approaches to support the next generation of LNP technologies.
Details
- Title: Subtitle
- Lipid Nanoparticle Development in Practice: Challenges and Collective Insights
- Creators
- Xiuling Lu - University of ConnecticutSheyda Ranjbar - University of ConnecticutFan Zhang - University of FloridaYahya Choonara - University of the WitwatersrandRyan M Pearson - University of Maryland, BaltimoreJohn Fetse - Binghamton UniversityRui He - University of IowaEsraa Mohamed - University of IowaAmalendu Ranjan - University of North TexasMuhammad Delwar Hussain - University of Maryland Eastern ShoreAshraf Hatim Osman Mohamed Kheir - University of Maryland Eastern ShoreChun-Wan Yen - GenentechAliasger K Salem - University of IowaMitra Mosharraf - HTD Biosystems (United States)
- Resource Type
- Journal article
- Publication Details
- Pharmaceutical research, Vol.43(2), pp.311-319
- DOI
- 10.1007/s11095-026-04025-3
- PMID
- 41572106
- NLM abbreviation
- Pharm Res
- ISSN
- 1573-904X
- eISSN
- 1573-904X
- Publisher
- Springer
- Language
- English
- Electronic publication date
- 01/22/2026
- Date published
- 02/2026
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Research Administration; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering
- Record Identifier
- 9985130240202771
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