Journal article
Lipid Trait Variants and the Risk of Non-Hodgkin Lymphoma Subtypes: A Mendelian Randomization Study
Cancer epidemiology, biomarkers & prevention, Vol.29(5), pp.1074-1078
05/2020
DOI: 10.1158/1055-9965.EPI-19-0803
PMCID: PMC7196490
PMID: 32108027
Abstract
Lipid traits have been inconsistently linked to risk of non-Hodgkin lymphoma (NHL). We examined the association of genetically predicted lipid traits with risk of diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), and marginal zone lymphoma (MZL) using Mendelian randomization (MR) analysis.
Genome-wide association study data from the InterLymph Consortium were available for 2,661 DLBCLs, 2,179 CLLs, 2,142 FLs, 824 MZLs, and 6,221 controls. SNPs associated (
< 5 × 10
) with high-density lipoprotein (HDL,
= 164), low-density lipoprotein (LDL,
= 137), total cholesterol (TC,
= 161), and triglycerides (TG,
= 123) were used as instrumental variables (IV), explaining 14.6%, 27.7%, 16.8%, and 12.8% of phenotypic variation, respectively. Associations between each lipid trait and NHL subtype were calculated using the MR inverse variance-weighted method, estimating odds ratios (OR) per standard deviation and 95% confidence intervals (CI).
HDL was positively associated with DLBCL (OR = 1.14; 95% CI, 1.00-1.30) and MZL (OR = 1.09; 95% CI, 1.01-1.18), while TG was inversely associated with MZL risk (OR = 0.90; 95% CI, 0.83-0.99), all at nominal significance (
< 0.05). A positive trend was observed for HDL with FL risk (OR = 1.08; 95% CI, 0.99-1.19;
= 0.087). No associations were noteworthy after adjusting for multiple testing.
We did not find evidence of a clear or strong association of these lipid traits with the most common NHL subtypes. While these IVs have been previously linked to other cancers, our findings do not support any causal associations with these NHL subtypes.
Our results suggest that prior reported inverse associations of lipid traits are not likely to be causal and could represent reverse causality or confounding.
Details
- Title: Subtitle
- Lipid Trait Variants and the Risk of Non-Hodgkin Lymphoma Subtypes: A Mendelian Randomization Study
- Creators
- Geffen Kleinstern - Mayo Clinic in FloridaNicola J Camp - Huntsman Cancer InstituteSonja I Berndt - National Cancer InstituteBrenda M Birmann - Brigham and Women's HospitalAlexandra Nieters - University of FreiburgPaige M Bracci - University of California, San FranciscoJames D McKay - Centre International de Recherche sur le CancerHervé Ghesquières - Hôpital Lyon SudQing Lan - National Cancer InstituteHenrik Hjalgrim - Statens Serum InstitutYolanda Benavente - Centro de Investigación Biomédica en Red de Epidemiología y Salud PúblicaAlain Monnereau - Sorbonne Paris CitéSophia S Wang - City Of Hope National Medical CenterYawei Zhang - Yale UniversityMark P Purdue - National Cancer InstituteAnne Zeleniuch-Jacquotte - New York University School of MedicineGraham G Giles - Cancer Council VictoriaRoel Vermeulen - University Medical Center UtrechtPierluigi Cocco - University of CagliariDemetrius Albanes - National Cancer InstituteLauren R Teras - American Cancer SocietyAngela R Brooks-Wilson - Simon Fraser UniversityClaire M Vajdic - UNSW SydneyEleanor Kane - University of YorkNeil E Caporaso - National Cancer InstituteKarin E Smedby - Karolinska InstitutetGilles Salles - Hôpital Lyon SudJoseph Vijai - Memorial Sloan Kettering Cancer CenterStephen J Chanock - National Cancer InstituteChristine F Skibola - Emory UniversityNathaniel Rothman - National Cancer InstituteSusan L Slager - Mayo ClinicJames R Cerhan - Mayo Clinic , Rochester, Minnesota.
- Resource Type
- Journal article
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.29(5), pp.1074-1078
- DOI
- 10.1158/1055-9965.EPI-19-0803
- PMID
- 32108027
- PMCID
- PMC7196490
- ISSN
- 1055-9965
- eISSN
- 1538-7755
- Grant note
- R01 CA092153 / NCI NIH HHS U58 DP000807 / NCCDPHP CDC HHS R01 CA154643 / NCI NIH HHS R01 CA200703 / NCI NIH HHS U01 HG007033 / NHGRI NIH HHS HHSN268201600003C / NHLBI NIH HHS R01 CA062006 / NCI NIH HHS N01 PC067008 / NCI NIH HHS UL1 TR002538 / NCATS NIH HHS R25 CA092049 / NCI NIH HHS N01 PC065064 / NCI NIH HHS P50 CA097274 / NCI NIH HHS R01 CA098122 / NCI NIH HHS HHSN268201600018C / NHLBI NIH HHS HHSN261201000035C / NCI NIH HHS HHSN268201600002C / NHLBI NIH HHS HHSN261201000140C / NCI NIH HHS N01CO12400 / NCI NIH HHS R01 CA129539 / NCI NIH HHS UL1 TR001863 / NCATS NIH HHS R01 CA134958 / NCI NIH HHS UM1 CA167552 / NCI NIH HHS N01 PC067010 / NCI NIH HHS P30 ES000260 / NIEHS NIH HHS CIHR UL1 TR000135 / NCATS NIH HHS HHSN268201600001C / NHLBI NIH HHS UM1 CA182934 / NCI NIH HHS HHSN261201000034C / NCI NIH HHS P01 CA087969 / NCI NIH HHS P30 CA008748 / NCI NIH HHS UM1 CA186107 / NCI NIH HHS R01 CA149445 / NCI NIH HHS R01 CA134674 / NCI NIH HHS HHSN268201600004C / NHLBI NIH HHS P30 CA042014 / NCI NIH HHS R01 CA049449 / NCI NIH HHS U01 CA118444 / NCI NIH HHS HHSN261201000026C / NCI NIH HHS P30 CA016087 / NCI NIH HHS N01 PC067009 / NCI NIH HHS HHSN261201000035I / NCI NIH HHS
- Language
- English
- Date published
- 05/2020
- Academic Unit
- Epidemiology
- Record Identifier
- 9984368083802771
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