Lipid-lowering effects of ezetimibe and simvastatin in combination

Nkechinyere Ijioma; Jennifer G Robinson

doi:10.1586/erc.10.179

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Journal article

Lipid-lowering effects of ezetimibe and simvastatin in combination

Nkechinyere Ijioma and Jennifer G Robinson

Expert review of cardiovascular therapy, Vol.9(2), pp.131-145

02/2011

DOI: 10.1586/erc.10.179

PMID: 21453210

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Abstract

Ezetimibe/simvastatin is a combination of a statin and a cholesterol absorption inhibitor. This article reviews current information on the pharmacology, clinical efficacy and safety of ezetimibe/simvastatin combination therapy as a lipid-lowering pharmacologic option. Focus is on the LDL cholesterol-lowering efficacy of ezetimibe/simvastatin. PubMed was searched for english-language articles from January 2005 to 14 April 2010 using the keywords 'ezetimibe and simvastatin' and 'hyperlipidemia'. Reviewers screened all records and only English language papers and human clinical studies were included in the review. References of these papers were reviewed for relevant articles, and retrospective studies were excluded. Limitations include the exclusion of non-English publications, the use of only one data source (PubMed), and the fact that most studies were of short duration and several studies were of low quality (nonrandomized trials or meta-analyses). Ezetimibe and simvastatin has proven to be a well-tolerated, effective lipid-lowering drug combination. It is effective in reducing LDL-cholesterol and triglycerides, and increasing HDL-cholesterol. It also decreases C-reactive protein and exhibits some pleiotropic effects in a variety of patient populations. More data are needed to evaluate its effect on cardiovascular events/outcomes.

Hypolipidemic Agents - adverse effects

Simvastatin - therapeutic use

Simvastatin - adverse effects

Humans

Hyperlipidemias - drug therapy

Azetidines - adverse effects

Azetidines - pharmacokinetics

Simvastatin - pharmacokinetics

Anticholesteremic Agents - adverse effects

Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics

Anticholesteremic Agents - pharmacokinetics

Animals

Anticholesteremic Agents - therapeutic use

Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects

Azetidines - therapeutic use

Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use

Hypolipidemic Agents - therapeutic use

Ezetimibe, Simvastatin Drug Combination

Hypolipidemic Agents - pharmacokinetics

Drug Combinations

Hyperlipidemias - complications

Details

Title: Subtitle: Lipid-lowering effects of ezetimibe and simvastatin in combination
Creators: Nkechinyere Ijioma - University of Iowa, Iowa City, IA, USA
Jennifer G Robinson
Resource Type: Journal article
Publication Details: Expert review of cardiovascular therapy, Vol.9(2), pp.131-145
DOI: 10.1586/erc.10.179
PMID: 21453210
NLM abbreviation: Expert Rev Cardiovasc Ther
eISSN: 1744-8344
Publisher: England
Language: English
Date published: 02/2011
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983996072502771

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