Lipid profile is associated with decreased fatigue in individuals with progressive multiple sclerosis following a diet-based intervention: Results from a pilot study

Kelly Fellows Maxwell; Terry Wahls; Richard W Browne; Linda Rubenstein; Babita Bisht; Catherine A Chenard; Linda Snetselaar; Bianca Weinstock-Guttman; Murali Ramanathan

doi:10.1371/journal.pone.0218075

Back

Journal article

Open access

Peer reviewed

Lipid profile is associated with decreased fatigue in individuals with progressive multiple sclerosis following a diet-based intervention: Results from a pilot study

Kelly Fellows Maxwell, Terry Wahls, Richard W Browne, Linda Rubenstein, Babita Bisht, Catherine A Chenard, Linda Snetselaar, Bianca Weinstock-Guttman and Murali Ramanathan

PloS one, Vol.14(6), pp.e0218075-e0218075

2019

DOI: 10.1371/journal.pone.0218075

PMCID: PMC6581256

PMID: 31211794

Files and links (1)

url

https://doi.org/10.1371/journal.pone.0218075View

Published (Version of record) Open Access

Abstract

To investigate associations between lipid profiles and fatigue in a cohort of progressive multiple sclerosis (MS) patients on a diet-based multimodal intervention. This pilot study included 18 progressive MS patients who participated in a prospective longitudinal study of fatigue following a diet-based multimodal intervention that included exercise, neuromuscular electrical stimulation and stress reduction. The diet recommended high intake of vegetables and fruits, encouraged consumption of animal and plant protein and excluded foods with gluten-containing grains, dairy and eggs. Fatigue was measured on the Fatigue Severity Scale (FSS) at baseline and every 3 months for 12 months. A lipid profile consisting of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC) and triglycerides (TG) was obtained on fasting blood samples at baseline and 12 months. FSS scores decreased from a baseline of 5.51 (95% CI: 4.86, 6.16) to a mean of 3.03 (95% CI: 2.23, 3.82) at 12 months (p < 0.001). At 12 months, increases in HDL-C (mean change: +6.0 mg/dl; 95% CI: 0.3, 12.0; p = 0.049) and decreases in BMI (mean change: -2.6 kg/m2; 95% CI: -3.6, -2.5; p < 0.001), LDL-C (mean change: -10.4 mg/dl; 95% CI:-19.7, -1.2; p = 0.029), TG (mean change: -29.2 mg/dl; 95% CI: -44.3, -14.2; p = 0.001), TG to HDL-C ratio (mean change: -0.6; 95% CI: -1.0, -0.3; p = 0.002) and TC to HDL-C ratio (mean change:-0.6; 95% CI: -1.0, -0.3; p = 0.003) were observed compared to baseline. Improvements in FSS were associated with increases in HDL-C (β = -0.05; 95% CI: -0.1, -0.0004; p = 0.048) and changes in TC (p = 0.005) from baseline to 12 months. Lipid profile variables are associated with improvements in fatigue in progressive MS patients on a diet-based multimodal intervention.

Exercise

Electric Stimulation

Multiple Sclerosis - blood

Cholesterol - blood

Humans

Middle Aged

Fatigue - complications

Fats - metabolism

Male

Carbohydrates - blood

Multiple Sclerosis - physiopathology

Lipids - blood

Adult

Cholesterol, LDL - blood

Female

Fatty Acids - blood

Severity of Illness Index

Fatigue - diet therapy

Fatigue - blood

Multiple Sclerosis - diet therapy

Multiple Sclerosis - complications

Pilot Projects

Animals

Diet

Triglycerides - blood

Cholesterol, HDL - blood

Fatigue - physiopathology

Details

Title: Subtitle: Lipid profile is associated with decreased fatigue in individuals with progressive multiple sclerosis following a diet-based intervention: Results from a pilot study
Creators: Kelly Fellows Maxwell - Department of Pharmaceutical Sciences, State University of New York, Buffalo, New York, United States of America
Terry Wahls - Department of Neurology, University of Iowa, Iowa City, Iowa, United States of America
Richard W Browne - Department of Biotechnical and Clinical Laboratory Sciences, State University of New York, Buffalo, New York, United States of America
Linda Rubenstein - Department of Epidemiology, University of Iowa, Iowa City, Iowa, United States of America
Babita Bisht - Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
Catherine A Chenard - Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
Linda Snetselaar - Department of Epidemiology, University of Iowa, Iowa City, Iowa, United States of America
Bianca Weinstock-Guttman - Department of Neurology, State University of New York, Buffalo, New York, United States of America
Murali Ramanathan - Department of Neurology, State University of New York, Buffalo, New York, United States of America
Resource Type: Journal article
Publication Details: PloS one, Vol.14(6), pp.e0218075-e0218075
DOI: 10.1371/journal.pone.0218075
PMID: 31211794
PMCID: PMC6581256
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: Public Library of Science; United States
Grant note: U54 TR001356 / NCATS NIH HHS
Language: English
Date published: 2019
Academic Unit: Neurology; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; General Internal Medicine; Internal Medicine
Record Identifier: 9984013111102771

Metrics

32 Record Views

30 Times Cited - Web of Science