Lipids, lysosomes, and autophagy

Bharat Jaishy; E Dale Abel

doi:10.1194/jlr.R067520

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Journal article

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Peer reviewed

Lipids, lysosomes, and autophagy

Bharat Jaishy and E Dale Abel

Journal of lipid research, Vol.57(9), pp.1619-1635

09/2016

DOI: 10.1194/jlr.R067520

PMCID: PMC5003162

PMID: 27330054

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Abstract

Lipids are essential components of a cell providing energy substrates for cellular processes, signaling intermediates, and building blocks for biological membranes. Lipids are constantly recycled and redistributed within a cell. Lysosomes play an important role in this recycling process that involves the recruitment of lipids to lysosomes via autophagy or endocytosis for their degradation by lysosomal hydrolases. The catabolites produced are redistributed to various cellular compartments to support basic cellular function. Several studies demonstrated a bidirectional relationship between lipids and lysosomes that regulate autophagy. While lysosomal degradation pathways regulate cellular lipid metabolism, lipids also regulate lysosome function and autophagy. In this review, we focus on this bidirectional relationship in the context of dietary lipids and provide an overview of recent evidence of how lipid-overload lipotoxicity, as observed in obesity and metabolic syndrome, impairs lysosomal function and autophagy that may eventually lead to cellular dysfunction or cell death.

Lipids - genetics

Lysosomes - metabolism

Signal Transduction

Humans

Lipid Metabolism - genetics

Metabolic Syndrome - metabolism

Autophagy - genetics

Metabolic Syndrome - pathology

Obesity - metabolism

Obesity - pathology

Details

Title: Subtitle: Lipids, lysosomes, and autophagy
Creators: Bharat Jaishy - Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242
E Dale Abel - Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242 DRCadmin@uiowa.edu
Resource Type: Journal article
Publication Details: Journal of lipid research, Vol.57(9), pp.1619-1635
DOI: 10.1194/jlr.R067520
PMID: 27330054
PMCID: PMC5003162
NLM abbreviation: J Lipid Res
ISSN: 0022-2275
eISSN: 1539-7262
Publisher: United States
Grant note: R01 HL108379 / NHLBI NIH HHS
Language: English
Date published: 09/2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984025286602771

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