Journal article
Lipophilic Pyridinium Bisphosphonates: Potent γδ T Cell Stimulators
Angewandte Chemie (International ed.), Vol.49(6), pp.1136-1138
02/01/2010
DOI: 10.1002/anie.200905933
PMCID: PMC2819003
PMID: 20039246
Abstract
Chain gang: Lipophilic pyridinium bisphosphonates containing long alkyl chains (see picture, P red, N blue, C orange, H gray) stimulate human γδ T cells expressing the Vγ2Vδ2 T cell receptor. Stimulation with such compounds is more potent than with zoledronate, which is active against breast and prostate cancer. The lipophilic bisphosphonates bind poorly to bone and are thus less likely to cause side effects associated with bisphosphonates in clinical use.
Details
- Title: Subtitle
- Lipophilic Pyridinium Bisphosphonates: Potent γδ T Cell Stimulators
- Creators
- Yonghui Zhang - Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana IL, 61801(USA), Fax: (+1) 217-244-0997Rong Cao - Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, 607 South Mathews Avenue, Urbana IL, 61801(USA)Fenglin Yin - Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, 607 South Mathews Avenue, Urbana IL, 61801(USA)Fu-Yang Lin - Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, 607 South Mathews Avenue, Urbana IL, 61801(USA)Hong Wang - Department of Internal Medicine, Division of Rheumatology and the Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, University of Iowa, EMRB 400F, Iowa City, IA 52242 (USA)Kilannin Krysiak - Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana IL, 61801(USA), Fax: (+1) 217-244-0997Joo-Hwan No - Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, 607 South Mathews Avenue, Urbana IL, 61801(USA)Dushyant Mukkamala - Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, 607 South Mathews Avenue, Urbana IL, 61801(USA)Kevin Houlihan - Department of Biochemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana IL, 61801(USA)Jikun Li - Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, 607 South Mathews Avenue, Urbana IL, 61801(USA)Craig T Morita - Department of Internal Medicine, Division of Rheumatology and the Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, University of Iowa, EMRB 400F, Iowa City, IA 52242 (USA)Eric Oldfield - Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana IL, 61801(USA), Fax: (+1) 217-244-0997
- Resource Type
- Journal article
- Publication Details
- Angewandte Chemie (International ed.), Vol.49(6), pp.1136-1138
- DOI
- 10.1002/anie.200905933
- PMID
- 20039246
- PMCID
- PMC2819003
- NLM abbreviation
- Angew Chem Int Ed Engl
- ISSN
- 1433-7851
- eISSN
- 1521-3773
- Publisher
- Wiley
- Number of pages
- 3
- Language
- English
- Date published
- 02/01/2010
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984094579802771
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