Journal article
Lipopolysaccharide-Induced Toxic Shock Syndrome in Rabbits
Methods in molecular biology (Clifton, N.J.), Vol.1396, pp.67-71
2016
DOI: 10.1007/978-1-4939-3344-0_5
PMID: 26676037
Abstract
Enhancement of susceptibility to lipopolysaccharide (LPS; endotoxin) is a defining characteristic of Staphylococcus aureus superantigens. At the time of this publication, there are 24 identified staphylococcal superantigens (SAgs), some of which have yet to be fully characterized. Testing the capacity of superantigens to potentiate LPS sensitivity is essential to characterize the role of these proteins in disease development. Here we describe how to perform studies of the enhancement of LPS-induced toxic shock syndrome in rabbits. This protocol also provides information on a second important activity of superantigens: the production of fever.
Details
- Title: Subtitle
- Lipopolysaccharide-Induced Toxic Shock Syndrome in Rabbits
- Creators
- Christopher S Stach - Department of Microbiology, University of Iowa, 51 Newton Road, Bowen Science Building 3-403, Iowa City, IA, 52242, USAPatrick M Schlievert - Department of Microbiology, University of Iowa, 51 Newton Road, Bowen Science Building 3-403, Iowa City, IA, 52242, USA. patrick-schlievert@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Methods in molecular biology (Clifton, N.J.), Vol.1396, pp.67-71
- Publisher
- United States
- DOI
- 10.1007/978-1-4939-3344-0_5
- PMID
- 26676037
- eISBN
- 9781493933440; 1493933442
- ISSN
- 1064-3745
- eISSN
- 1940-6029
- Language
- English
- Date published
- 2016
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001153102771
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