Journal article
Lipoprotein particle concentrations may explain the absence of coronary protection in the women's health initiative hormone trials
Arteriosclerosis, thrombosis, and vascular biology, Vol.28(9), pp.1666-1671
09/2008
DOI: 10.1161/ATVBAHA.108.170431
PMCID: PMC2701372
PMID: 18599797
Abstract
The Women's Health Initiative randomized hormone trials unexpectedly demonstrated an increase in early coronary events. In an effort to explain this finding, we examined lipoprotein particle concentrations and their interactions with hormone therapy in a case-control substudy.
We randomized 16 608 postmenopausal women with intact uterus to conjugated estrogens 0.625 mg with medroxyprogesterone acetate 2.5 mg daily or to placebo, and 10 739 women with prior hysterectomy to conjugated estrogens 0.625 mg daily or placebo, and measured lipoprotein subclasses by nuclear magnetic resonance spectroscopy at baseline and year 1 in 354 women with early coronary events and matched controls. Postmenopausal hormone therapy raised high-density lipoprotein cholesterol and particle concentration and reduced low-density lipoprotein cholesterol (LDL-C; all P<0.001 versus placebo). In contrast, neither unopposed estrogen nor estrogen with progestin lowered low-density lipoprotein particle concentration (LDL-P).
Postmenopausal hormone therapy-induced reductions in LDL-C were not paralleled by favorable effects on LDL-P. This finding may account for the absence of coronary protection conferred by estrogen in the randomized hormone trials.
Details
- Title: Subtitle
- Lipoprotein particle concentrations may explain the absence of coronary protection in the women's health initiative hormone trials
- Creators
- Judith Hsia - Department of Medicine, George Washington University, Washington, DC, USA. judith.hsia@astrazeneca.comJames D OtvosJacques E RossouwLieLing WuSylvia Wassertheil-SmollerSusan L HendrixJennifer G RobinsonBernedine Lund - Fred Hutch Cancer CenterLewis H KullerWomen's Health Initiative Research Group
- Resource Type
- Journal article
- Publication Details
- Arteriosclerosis, thrombosis, and vascular biology, Vol.28(9), pp.1666-1671
- Publisher
- United States
- DOI
- 10.1161/ATVBAHA.108.170431
- PMID
- 18599797
- PMCID
- PMC2701372
- ISSN
- 1079-5642
- eISSN
- 1524-4636
- Grant note
- N01WH42123 / WHI NIH HHS N01WH32111 / WHI NIH HHS N01WH42132 / WHI NIH HHS N01WH42118 / WHI NIH HHS N01WH42114 / WHI NIH HHS N01WH42110 / WHI NIH HHS N01WH32106 / WHI NIH HHS N01WH32119 / WHI NIH HHS N01WH32115 / WHI NIH HHS N01WH32102 / WHI NIH HHS N01WH24152 / WHI NIH HHS N01WH32101 / WHI NIH HHS N01WH42131 / WHI NIH HHS N01WH42108 / WHI NIH HHS N01WH42126 / WHI NIH HHS N01WH42113 / WHI NIH HHS N01WH42117 / WHI NIH HHS N01WH44221 / WHI NIH HHS N01WH32109 / WHI NIH HHS N01WH32105 / WHI NIH HHS N01WH32118 / WHI NIH HHS N01WH42122 / WHI NIH HHS N01WH42107 / WHI NIH HHS N01WH42130 / WHI NIH HHS N01WH42125 / WHI NIH HHS N01WH42112 / WHI NIH HHS N01 WH042108-011 / WHI NIH HHS N01WH42129 / WHI NIH HHS N01WH32122 / WHI NIH HHS N01WH42116 / WHI NIH HHS N01WH32108 / WHI NIH HHS N01 WH022110-024 / WHI NIH HHS N01WH32113 / WHI NIH HHS N01WH32100 / WHI NIH HHS N01WH42121 / WHI NIH HHS N01WH42115 / WHI NIH HHS N01WH42124 / WHI NIH HHS N01WH32112 / WHI NIH HHS N01WH42119 / WHI NIH HHS N01WH22110 / WHI NIH HHS N01WH42111 / WHI NIH HHS N01WH42120 / WHI NIH HHS N01WH42109 / WHI NIH HHS
- Language
- English
- Date published
- 09/2008
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983995144002771
Metrics
20 Record Views