Journal article
Lipoprotein(a) in Youth and Prediction of Major Cardiovascular Outcomes in Adulthood
Circulation (New York, N.Y.), Vol.147(1), pp.23-31
01/03/2023
DOI: 10.1161/CIRCULATIONAHA.122.060667
PMCID: PMC9797445
PMID: 36440577
Abstract
Elevated lipoprotein(a) [Lp(a)] is a common risk factor for cardiovascular disease outcomes with unknown mechanisms. We examined its potential role in identifying youths who are at increased risk of developing adult atherosclerotic cardiovascular disease (ASCVD).
Lp(a) levels measured in youth 9 to 24 years of age were linked to adult ASCVD and carotid intima-media thickness in the YFS (Cardiovascular Risk in Young Finns Study), in which 95 of the original 3596 participants (2.7%) recruited as children have been diagnosed with ASCVD at a median of 47 years of age. Results observed in YFS were replicated with the use of data for White participants from the BHS (Bogalusa Heart Study). In BHS, 587 White individuals had data on youth Lp(a) (measured at 8-17 years of age) and information on adult events, including 15 cases and 572 noncases. Analyses were performed with the use of Cox proportional hazard regression.
In YFS, those who had been exposed to high Lp(a) level in youth [defined as Lp(a) ≥30 mg/dL] had ≈2 times greater risk of developing adult ASCVD compared with nonexposed individuals (hazard ratio, 2.0 [95% CI, 1.4-2.6]). Youth risk factors, including Lp(a), low-density lipoprotein cholesterol, body mass index, and smoking, were all independently associated with higher risk. In BHS, in an age- and sex-adjusted model, White individuals who had been exposed to high Lp(a) had 2.5 times greater risk (95% CI, 0.9-6.8) of developing adult ASCVD compared with nonexposed individuals. When also adjusted for low-density lipoprotein cholesterol and body mass index, the risk associated with high Lp(a) remained unchanged (hazard ratio, 2.4 [95% CI, 0.8-7.3]). In a multivariable model for pooled data, individuals exposed to high Lp(a) had 2.0 times greater risk (95% CI, 1.0-3.7) of developing adult ASCVD compared with nonexposed individuals. No association was detected between youth Lp(a) and adult carotid artery thickness in either cohort or pooled data.
Elevated Lp(a) level identified in youth is a risk factor for adult atherosclerotic cardiovascular outcomes but not for increased carotid intima-media thickness.
Details
- Title: Subtitle
- Lipoprotein(a) in Youth and Prediction of Major Cardiovascular Outcomes in Adulthood
- Creators
- Olli Raitakari - University of TurkuNoora Kartiosuo - Turku University HospitalKatja Pahkala - Turku University HospitalNina Hutri-Kähönen - Tampere UniversityLydia A Bazzano - Tulane UniversityWei Chen - Tulane UniversityElaine M Urbina - Cincinnati Children's Hospital Medical CenterDavid R Jacobs Jr - University of MinnesotaAlan Sinaiko - University of MinnesotaJulia Steinberger - University of MinnesotaTrudy Burns - University of IowaStephen R Daniels - Children's Hospital ColoradoAlison Venn - University of TasmaniaJessica G Woo - Cincinnati Children's Hospital Medical CenterTerry Dwyer - University of OxfordMarkus Juonala - Turku University HospitalJorma Viikari - University of Turku
- Resource Type
- Journal article
- Publication Details
- Circulation (New York, N.Y.), Vol.147(1), pp.23-31
- DOI
- 10.1161/CIRCULATIONAHA.122.060667
- PMID
- 36440577
- PMCID
- PMC9797445
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Grant note
- R01 HL121230 / NHLBI NIH HHS
- Language
- English
- Date published
- 01/03/2023
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984364449302771
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