Journal article
Lipotoxicity in the heart
Biochimica et biophysica acta. Molecular and cell biology of lipids, Vol.1801(3), pp.311-319
2010
DOI: 10.1016/j.bbalip.2009.09.023
PMCID: PMC2823976
PMID: 19818871
Abstract
Obesity and insulin resistance are associated with ectopic lipid deposition in multiple tissues, including the heart. Excess lipid may be stored as triglycerides, but are also shunted into non-oxidative pathways that disrupt normal cellular signaling leading to organ dysfunction and in some cases apoptosis, a process termed lipotoxicity. Various pathophysiological mechanisms have been proposed to lead to lipotoxic tissue injury, which might vary by cell type. Specific mechanisms by which lipotoxicity alter cardiac structure and function are incompletely understood, but are beginning to be elucidated. This review will focus on mechanisms that have been proposed to lead to lipotoxic injury in the heart and will review the state of knowledge regarding potential causes and correlates of increased myocardial lipid content in animal models and humans. We will seek to highlight those areas where additional research is warranted.
Details
- Title: Subtitle
- Lipotoxicity in the heart
- Creators
- Adam R WendeE. Dale Abel
- Resource Type
- Journal article
- Publication Details
- Biochimica et biophysica acta. Molecular and cell biology of lipids, Vol.1801(3), pp.311-319
- DOI
- 10.1016/j.bbalip.2009.09.023
- PMID
- 19818871
- PMCID
- PMC2823976
- NLM abbreviation
- Biochim Biophys Acta Mol Cell Biol Lipids
- ISSN
- 1388-1981
- eISSN
- 1879-2618
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984024558302771
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