Journal article
Listeria monocytogenes: a model pathogen to study antigen-specific memory CD8 T cell responses
Seminars in immunopathology, Vol.37(3), pp.301-310
05/2015
DOI: 10.1007/s00281-015-0477-5
PMCID: PMC4439301
PMID: 25860798
Abstract
Memory CD8 T cells play a critical role in providing protection to immune hosts by orchestrating rapid elimination of pathogen-infected cells after re-infection. Systemic bacterial infection with
Listeria monocytogenes
has been a favored approach for researchers to characterize pathogen-specific CD8 T cell responses, and in-depth understanding of
L. monocytogenes
biology has provided invaluable experimental tools that have been used to increase our understanding of memory CD8 T cell differentiation. Here, we describe how the tools from this murine model system of infection have been utilized to characterize pathogen-specific CD8 T cells in inbred and genetically diverse outbred hosts as they undergo naïve-to-memory CD8 T cell differentiation
in vivo
. We also discuss how studying
L. monocytogenes
-evoked CD8 T cell responses have provided insight on the degree of diminished T cell immunity in clinically relevant conditions such as sepsis and obesity. Overall, this review will highlight how infection with the intracellular pathogen
L. monocytogenes
has enabled analysis of systemic CD8 T cell responses and greatly contributed to what is known about memory CD8 T cell generation and differentiation.
Details
- Title: Subtitle
- Listeria monocytogenes: a model pathogen to study antigen-specific memory CD8 T cell responses
- Creators
- Shaniya H Khan - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USAVladimir P Badovinac - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Seminars in immunopathology, Vol.37(3), pp.301-310
- DOI
- 10.1007/s00281-015-0477-5
- PMID
- 25860798
- PMCID
- PMC4439301
- NLM abbreviation
- Semin Immunopathol
- ISSN
- 1863-2297
- eISSN
- 1863-2300
- Language
- English
- Date published
- 05/2015
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984047635902771
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