Journal article
Lithium-Associated Hyperparathyroidism: A Pooled Analysis
O.R.L. Journal for oto-rhino-laryngology and its related specialties, Vol.77(5), pp.273-280
01/01/2015
DOI: 10.1159/000431230
PMID: 26315685
Abstract
Background: Lithium treatment has been associated with hyperparathyroidism (HPT). However, there are conflicting data regarding the rate of single- (SGD) versus multiple-gland disease (MGD) as well as the optimum surgical approach in these cases. Methods: Published data were identified through systematic electronic literature searches. Studies that fulfilled the preset inclusion criteria were analyzed (n = 12). Results: These studies documented 210 lithium-associated HPT (LAH) cases. Of these, 103 (49%) were due to SGD and 107 (51%) due to MGD. The unadjusted odds ratio of having multiple LAH compared to sporadic HPT was 3.44 (95% confidence interval 2.5907-4.5633; p < 0.0001). The sensitivity of preoperative sestamibi and sonography for SGD was 66-100 and 75-82%, respectively. The sensitivity for MGD was 9-67% for both. Intraoperative parathyroid hormone monitoring was utilized in 6 studies. Three studies recommended minimally invasive parathyroidectomy (MIP), while the other 3 recommended bilateral exploration. Conclusion: LAH is a relatively frequent condition among patients on lithium, and calcium monitoring should be performed initially and longitudinally. Almost half of the LAH cases are due to SGD. MIP should be the optimum surgical approach. (C) 2015 S. Karger AG, Basel
Details
- Title: Subtitle
- Lithium-Associated Hyperparathyroidism: A Pooled Analysis
- Creators
- Yasin Ibrahim - Tulane UniversitySalah Edin Mohamed - Tulane UniversityAhmed Deniwar - Tulane UniversityZaid H. Al-Qurayshi - Tulane UniversityEmad Kandil - Tulane University
- Resource Type
- Journal article
- Publication Details
- O.R.L. Journal for oto-rhino-laryngology and its related specialties, Vol.77(5), pp.273-280
- Publisher
- Karger
- DOI
- 10.1159/000431230
- PMID
- 26315685
- ISSN
- 0301-1569
- eISSN
- 1423-0275
- Number of pages
- 8
- Language
- English
- Date published
- 01/01/2015
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984702946102771
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