Journal article
Lithium Fails to Protect Dopaminergic Neurons in the 6-OHDA Model of Parkinson’s Disease
Neurochemical research, Vol.36(3), pp.367-374
03/2011
DOI: 10.1007/s11064-010-0368-z
PMID: 21203835
Abstract
Lithium has been used for the treatment of bipolar mood disorder and is shown to have neuroprotective properties. Since lithium inhibits the activity of glycogen synthase kinase 3 (GSK3) which is implicated in various human diseases, particularly neurodegenerative diseases, the therapeutic potential of lithium receives great attention. Parkinson’s disease (PD) is the second most common neurodegenerative disease, characterized by the pathological loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Intranigral injection of the catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA) causes selective and progressive degeneration of dopaminergic neurons in SNpc, and is a commonly used animal model of PD. The current study was designated to determine whether lithium is effective in alleviating 6-OHDA-induced neurodegeneration in the SNpc of rats. We demonstrated that chronic subcutaneous administration of lithium inhibited GSK3 activity in the SNpc, which was evident by an increase in phosphorylation of GSK3β at serine 9, cyclin D1 expression, and a decrease in tau phosphorylation. 6-OHDA did not affect GSK3 activity in the SNpc. Moreover, lithium was unable to alleviate 6-OHDA-induced degeneration of SNpc dopaminergic neurons. The results suggest that GSK3 is minimally involved in the neurodegeneration in the rat 6-OHDA model of PD.
Details
- Title: Subtitle
- Lithium Fails to Protect Dopaminergic Neurons in the 6-OHDA Model of Parkinson’s Disease
- Creators
- Yue Yong - Chinese Academy of SciencesHanqing Ding - Chinese Academy of SciencesZhiqin Fan - Chinese Academy of SciencesJia Luo - Chinese Academy of SciencesZun-Ji Ke - Shanghai Institutes for Biological Sciences
- Resource Type
- Journal article
- Publication Details
- Neurochemical research, Vol.36(3), pp.367-374
- Publisher
- Springer US
- DOI
- 10.1007/s11064-010-0368-z
- PMID
- 21203835
- ISSN
- 0364-3190
- eISSN
- 1573-6903
- Language
- English
- Date published
- 03/2011
- Academic Unit
- Pathology
- Record Identifier
- 9984186433902771
Metrics
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