Journal article
Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure
Scientific reports, Vol.9(1), pp.630-630
01/24/2019
DOI: 10.1038/s41598-018-37198-y
PMCID: PMC6345819
PMID: 30679672
Abstract
Fibroblast Growth Factor 21 (FGF21) elicits an array of metabolic effects. However, the physiological role of FGF21 during thermal challenges is not clear. In this study, we assessed the tissue source of FGF21 and its site of action to regulate core body temperature in response to cold. Using mice lacking FGF21 specifically in the liver (FGF21 LivKO) or adipose tissues (FGF21 AdipoKO), we performed a series of cold exposure studies to examine the tissue specific induction of FGF21 in response to cold. We also examined the physiological site of FGF21 action during cold exposure by impairing FGF21 signaling to adipose tissues or the central nervous system (CNS) using genetic ablation of the FGF21 co-receptor β-klotho in adipose tissues (KLB AdipoKO) or pharmacological blockage of FGF21 signaling. We found that only liver-derived FGF21 enters circulation during acute cold exposure and is critical for thermoregulation. While FGF21 signaling directly to adipose tissues during cold is dispensable for thermoregulation, central FGF21 signaling is necessary for maximal sympathetic drive to brown adipose tissue to maintain thermoregulation during cold. These data demonstrate a previously unrecognized role for FGF21 in the maintenance of body temperature in response to cold.
Details
- Title: Subtitle
- Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure
- Creators
- Magdalene Ameka - Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USAKathleen R Markan - Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USADonald A Morgan - Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USALucas D BonDurant - Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USASharon O Idiga - Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USAMeghan C Naber - Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USAZhiyong Zhu - Department of Veterans Affairs Medical Center, Iowa City, IA, 52242, USALeonid V Zingman - Department of Veterans Affairs Medical Center, Iowa City, IA, 52242, USAJustin L Grobe - Obesity Research and Education Initiative, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USAKamal Rahmouni - Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USAMatthew J Potthoff - Obesity Research and Education Initiative, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA. matthew-potthoff@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.9(1), pp.630-630
- DOI
- 10.1038/s41598-018-37198-y
- PMID
- 30679672
- PMCID
- PMC6345819
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Publisher
- England
- Grant note
- I01 BX000718 / BLRD VA R01 DK106104 / NIDDK NIH HHS P01 HL084207 / NHLBI NIH HHS R01 HL134850 / NHLBI NIH HHS K01 DK111758 / NIDDK NIH HHS
- Language
- English
- Date published
- 01/24/2019
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040285302771
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