Journal article
Liver Transplantation as a Curative Approach for Patients With Nonresectable Colorectal Liver Metastases
Experimental and clinical transplantation, Vol.20(2), pp.113-121
02/01/2022
DOI: 10.6002/ect.2021.0421
PMID: 35282808
Abstract
Objectives: Liver transplant is emerging as a potential treatment option for patients with isolated colorectal liver metastasis. In this review article, we analyzed the published literature on liver transplant outcomes in such patients.
Materials and Methods: Four prospective studies documenting the clinical outcomes in patients with colorectal liver metastasis who underwent liver transplant were analyzed to study the feasibility of liver transplant in such patients.
Results: The SECA-II trial demonstrated the highest overall survival of 100%, 83%, and 83% at 1, 3, and 5 years, respectively, and disease-free survival of 53%, 44%, and 35%, respectively, with a narrow inclusion criterion. Conversely, extended criteria for selection and donors in arm D of the same trial resulted in median overall survival and disease-free survival of 18 and 4 months, respectively.
Conclusions: Liver transplant provided more prolonged overall survival compared with other therapeutic modalities. Patients with isolated colorectal liver metastasis of less aggressive biology, good performance status, at least 6 weeks of chemotherapy, low clinical risk scores, and negative nodal disease should be considered for patient selection. Moreover, exclusion criteria consisting of patients with the right-sided primary tumor, less than 3 years to liver transplant after diagnosis, and elevation of carbohydrate antigen (CA19-9) in the presence of BRAF mutation should be explored.
Details
- Title: Subtitle
- Liver Transplantation as a Curative Approach for Patients With Nonresectable Colorectal Liver Metastases
- Creators
- Fasih Ali Ahmed - Univ Hosp Cleveland Med Ctr, Div Surg Oncol, Dept Surg, Cleveland, OH 44106 USAYong K. Kwon - Univ Southern Calif, Keck Sch Med, Los Angeles, CA 90007 USAShannon Zielsdorf - Univ Southern Calif, Keck Sch Med, Los Angeles, CA 90007 USAJeffrey T. Cooper - Boston UniversityHassan Aziz - Tufts University
- Resource Type
- Journal article
- Publication Details
- Experimental and clinical transplantation, Vol.20(2), pp.113-121
- Publisher
- Baskent Univ
- DOI
- 10.6002/ect.2021.0421
- PMID
- 35282808
- ISSN
- 1304-0855
- eISSN
- 2146-8427
- Number of pages
- 9
- Language
- English
- Date published
- 02/01/2022
- Academic Unit
- Surgery
- Record Identifier
- 9984701555602771
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