Journal article
Living donor liver transplantation for non-alcoholic steatohepatitis: A single center experience
Hepatology research, Vol.44(10), pp.E3-E10
10/01/2014
DOI: 10.1111/hepr.12200
PMID: 23834427
Abstract
Aim: The number of patients referred for liver transplantation (LT) with non-alcoholic steatohepatitis (NASH) continues to increase, but information about living donor liver transplantation (LDLT) for NASH is scarce. We conducted this study to document the details of LDLT for NASH in a Japanese LT center.
Methods: Among all LDLT recipients in our institution from March 1996 to March 2013 (n = 425), we identified seven patients that underwent LDLT for NASH.
Results: Of all the seven recipients, most of the patients (86%) were obese. The median follow-up period post-LDLT was 5.3 years. All were alive at the last follow-up. Recurrent NASH was detected in one patient (14%), and no recurrent hepatic steatosis was detected among the remaining six recipients on prospectively performed ultrasonography. No significant comorbidities were observed following donor surgery among the respective living donors during the follow-up period. We also retrospectively reviewed 22 patients with NASH-related end-stage liver disease (ESLD) who were evaluated but rejected for LDLT during the same period. The reasons for rejection for LDLT were presumably associated with the nature of NAFLD/NASH in either potential recipients or donors.
Conclusion: The post-transplant outcome of LDLT for NASH-related ESLD in our institution was feasible, although the sample size was small. Further studies in a larger patient cohort are warranted to investigate the long-term outcome of LDLT for NASH, both for recipients and living donors.
Details
- Title: Subtitle
- Living donor liver transplantation for non-alcoholic steatohepatitis: A single center experience
- Creators
- Tomohiro Tanaka - University of Tokyo HospitalYasuhiko Sugawara - The University of TokyoSumihito Tamura - The University of TokyoJunichi Kaneko - The University of TokyoYutaka Takazawa - The University of TokyoTaku Aoki - The University of TokyoKiyoshi Hasegawa - The University of TokyoYoshihiro Sakamoto - The University of TokyoNoriyo Yamashiki - University of Tokyo HospitalNorihiro Kokudo - The University of Tokyo
- Resource Type
- Journal article
- Publication Details
- Hepatology research, Vol.44(10), pp.E3-E10
- Publisher
- Wiley
- DOI
- 10.1111/hepr.12200
- PMID
- 23834427
- ISSN
- 1386-6346
- eISSN
- 1872-034X
- Number of pages
- 8
- Grant note
- Ministry of Health, Labor and Welfare of Japan; Ministry of Health, Labour and Welfare, Japan Ministry of Education, Culture, Sports, Science and Technology of Japan; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
- Language
- English
- Date published
- 10/01/2014
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984359859202771
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