Journal article
Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond
The Journal of neuroscience, Vol.26(27), pp.7151-7155
07/05/2006
DOI: 10.1523/JNEUROSCI.1790-06.2006
PMCID: PMC6673953
PMID: 16822971
Abstract
Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).
Details
- Title: Subtitle
- Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond
- Creators
- Aaron W Grossman - Beckman Institute, University of Illinois at Urbana--Champaign, Urbana, Illinois 61801, USAGeorgina M AldridgeIvan Jeanne WeilerWilliam T Greenough
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.26(27), pp.7151-7155
- Publisher
- United States
- DOI
- 10.1523/JNEUROSCI.1790-06.2006
- PMID
- 16822971
- PMCID
- PMC6673953
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Grant note
- HD07333 / NICHD NIH HHS MH35321 / NIMH NIH HHS AG10154 / NIA NIH HHS
- Language
- English
- Date published
- 07/05/2006
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984020746602771
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