Local recurrence rates of superficial versus deep soft tissue sarcoma

James S. Lin; Lisa Coleman; Ryan T. Voskuil; Azeem Malik; Joel L. Mayerson; Thomas J. Scharschmidt

doi:10.1007/s00402-024-05326-1

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Local recurrence rates of superficial versus deep soft tissue sarcoma

Journal article

Peer reviewed

Local recurrence rates of superficial versus deep soft tissue sarcoma

James S. Lin, Lisa Coleman, Ryan T. Voskuil, Azeem Malik, Joel L. Mayerson and Thomas J. Scharschmidt

Archives of orthopaedic and trauma surgery, Vol.144(7), pp.2967-2973

07/01/2024

DOI: 10.1007/s00402-024-05326-1

PMID: 38850420

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Abstract

Introduction Soft tissue sarcomas are a group of malignancies that commonly occur in the extremities. As deep lesions may exist within the confines of the muscular fascia, we postulate that local recurrence rates are higher for superficial soft tissue sarcomas managed by the standard of care. Materials and methods A retrospective review was performed on 90 patients who underwent surgical resection of soft tissue sarcomas of the extremity from 2007 to 2015. Patients with minimum 2-year follow-up and adequate operative, pathologic, and clinical outcomes data were included. Results Mean age was 54 ± 18 years with 49 (54.4%) patients being male. Lesions in 77.8% of cases were deep, and 22.2% were superficial to fascia. Following the index surgical resection, a total of 33 (36.7%) patients had positive margins. A total of 17 (18.9%) patients had a local recurrence. Overall, 3-year survival was 92.7%, and 5-year survival was 79.0%. Five-year recurrence-free survival of deep sarcomas was 91.1% versus 58.2% of superficial lesions ( p = 0.006). Patients with higher tumor depth had lower odds of experiencing a local recurrence (HR 0.26 [95% CI 0.09–0.72]). Local recurence rates was also associated with positive surgical margins on initial resection (33.3% versus 12.3%) ( p = 0.027). Conclusions In this series, superficial tumor depth was associated with local recurrence of soft tissue sarcomas of the extremity following surgical resection. Positive surgical margins was also associated with local recurrence.

Medicine

Medicine & Public Health

Orthopaedic Surgery

Orthopedics

Details

Title: Subtitle: Local recurrence rates of superficial versus deep soft tissue sarcoma
Creators: James S. Lin - The Ohio State University Wexner Medical Center
Lisa Coleman - The Ohio State University Wexner Medical Center
Ryan T. Voskuil - The Ohio State University Wexner Medical Center
Azeem Malik - The Ohio State University Wexner Medical Center
Joel L. Mayerson - The Ohio State University Wexner Medical Center
Thomas J. Scharschmidt - The Ohio State University
Resource Type: Journal article
Publication Details: Archives of orthopaedic and trauma surgery, Vol.144(7), pp.2967-2973
DOI: 10.1007/s00402-024-05326-1
PMID: 38850420
ISSN: 1434-3916
eISSN: 1434-3916
Publisher: Springer Berlin Heidelberg
Number of pages: 7
Language: English
Date published: 07/01/2024
Academic Unit: Orthopedics and Rehabilitation
Record Identifier: 9985237501002771

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