Journal article
Localization and Behaviors in Null Mice Suggest that ASIC1 and ASIC2 Modulate Responses to Aversive Stimuli
Genes, brain and behavior, Vol.13(2), pp.179-194
02/2014
DOI: 10.1111/gbb.12108
PMCID: PMC3998777
PMID: 24256442
Abstract
Acid sensing ion channels (ASICs) generate H
+
-gated Na
+
currents that contribute to neuronal function and animal behavior. Like ASIC1, ASIC2 subunits are expressed in the brain and multimerize with ASIC1 to influence acid-evoked currents and facilitate ASIC1 localization to dendritic spines. To better understand how ASIC2 contributes to brain function, we localized the protein and tested the behavioral consequences of
ASIC2
gene disruption. For comparison, we also localized ASIC1 and studied
ASIC1
−/−
mice. ASIC2 was prominently expressed in areas of high synaptic density, and with a few exceptions, ASIC1 and ASIC2 localization exhibited substantial overlap. Loss of ASIC1 or ASIC2 decreased freezing behavior in contextual and auditory cue fear conditioning assays, in response to predator odor, and in response to CO
2
inhalation. In addition, loss of ASIC1 or ASIC2 increased activity in a forced swim assay. These data suggest that ASIC2, like ASIC1, plays a key role in determining the defensive response to aversive stimuli. They also raise the question of whether gene variations in both
ASIC1
and
ASIC2
might affect fear and panic in humans.
Details
- Title: Subtitle
- Localization and Behaviors in Null Mice Suggest that ASIC1 and ASIC2 Modulate Responses to Aversive Stimuli
- Creators
- Margaret P Price - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242Huiyu Gong - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242Meredith G Parsons - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242Jacob R Kundert - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242Leah R Reznikov - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242Luisa Bernardinelli - Department of Brain and Behavioral Sciences, University of Pavia Via Bassi 21, 27100 Pavia ItalyKathryn Chaloner - Department of Biostatistics, College of Public Health University of Iowa, Iowa City, Iowa 52242Gordon F Buchanan - Department of Neurology, Yale University School of Medicine New Haven, Connecticut, 06520John A Wemmie - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242George B Richerson - Department of Neurology, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242Martin D Cassell - Department of Anatomy and Cell Biology, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242Michael J Welsh - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- Genes, brain and behavior, Vol.13(2), pp.179-194
- DOI
- 10.1111/gbb.12108
- PMID
- 24256442
- PMCID
- PMC3998777
- ISSN
- 1601-1848
- eISSN
- 1601-183X
- Language
- English
- Date published
- 02/2014
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Psychiatry; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Pathology; Iowa Neuroscience Institute; Interdisciplinary Programs; Neurosurgery; Internal Medicine
- Record Identifier
- 9984013206002771
Metrics
28 Record Views