Journal article
Localization of Unknown Primary Site with 68Ga-DOTATOC PET/CT in Patients with Metastatic Neuroendocrine Tumor
The Journal of nuclear medicine (1978), Vol.58(7), pp.1054-1057
07/2017
DOI: 10.2967/jnumed.116.180984
PMCID: PMC5493006
PMID: 28153957
Abstract
Localization of the site of the unknown primary tumor is critical for surgical treatment of patients presenting with neuroendocrine tumor (NET) with metastases.
Methods:
Forty patients with metastatic NET and unknown primary site underwent
68
Ga-DOTATOC PET/CT in a single-site prospective study. The
68
Ga-DOTATOC PET/CT was considered true-positive if the positive primary site was confirmed by histology or follow-up imaging. The scan was considered false-positive if no primary lesion was found corresponding to the
68
Ga-DOTATOC–positive site. All negative scans for primary tumor were considered false-negative. A scan was classified unconfirmed if
68
Ga-DOTATOC PET/CT suggested a primary, however, no histology was obtained and imaging follow-up was not confirmatory.
Results:
The true-positive, false-positive, false-negative, and unconfirmed rates for unknown primary tumor were 38%, 7%, 50%, and 5%, respectively.
Conclusion:
68
Ga-DOTATOC PET/CT is an effective modality in the localization of unknown primary in patients with metastatic NET.
Details
- Title: Subtitle
- Localization of Unknown Primary Site with 68Ga-DOTATOC PET/CT in Patients with Metastatic Neuroendocrine Tumor
- Creators
- Yusuf Menda - Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IowaThomas M O’Dorisio - Department of Medicine, University of Iowa Carver College of Medicine, Iowa City, IowaJames R Howe - Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IowaMichael Schultz - Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IowaJoseph S Dillon - Department of Medicine, University of Iowa Carver College of Medicine, Iowa City, IowaDavid Dick - Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IowaG. Leonard Watkins - Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IowaTimothy Ginader - Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, IowaDavid L Bushnell - Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IowaJohn J Sunderland - Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IowaGideon K.D Zamba - Department of Biostatistics, University of Iowa College of Public Health, Iowa City, Iowa; andMichael Graham - Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IowaM. Sue O’Dorisio - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of nuclear medicine (1978), Vol.58(7), pp.1054-1057
- Publisher
- Society of Nuclear Medicine
- DOI
- 10.2967/jnumed.116.180984
- PMID
- 28153957
- PMCID
- PMC5493006
- ISSN
- 0161-5505
- eISSN
- 1535-5667
- Language
- English
- Date published
- 07/2017
- Academic Unit
- Radiology; Stead Family Department of Pediatrics; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Surgery; Physics and Astronomy; Radiation Oncology; Internal Medicine
- Record Identifier
- 9983997460902771
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