Journal article
Localization of a Medial Temporal Lobe - Precuneus Network for Time Orientation
Annals of neurology, Vol.94(3), pp.421-433
09/2023
DOI: 10.1002/ana.26681
PMCID: PMC10524450
PMID: 37183996
Appears in UI Libraries Support Open Access
Abstract
Time orientation is a fundamental cognitive process in which one's personal sense of time is matched with a universal reference. Time orientation is commonly assessed through mental status examination, yet its neural correlates remain unclear. Large lesions have been associated with deficits in time orientation, but the regional anatomy implicated in time disorientation is not well established. The current study investigates the anatomy of time disorientation and its network correlates in patients with focal brain lesions.
Time orientation was assessed three months or more after lesion onset using the Benton Temporal Orientation Test (BTOT) in 550 patients with acquired, focal brain lesions, 39 of whom were impaired with a BTOT score of three or worse. Multivariate lesion-symptom mapping and lesion network mapping were used to evaluate the anatomy and networks associated with time disorientation. Performance on a variety of neuropsychological tests was compared between the time oriented and time disoriented group.
Lesion-symptom mapping showed that lesions of the precuneus, medial temporal lobes (MTL), and occipito-temporal cortex were associated with time disorientation (r = 0.264, p < .001). Lesion network mapping using normative connectome data demonstrated that these regional findings occurred along a network that includes white and grey matter connecting the precuneus and MTL. There was a strong behavioral and anatomical association of time disorientation with memory impairment, such that the two processes could not be fully disentangled.
We interpret these findings as novel evidence for a network involving the precuneus and the medial temporal lobe in supporting time orientation. This article is protected by copyright. All rights reserved.
Details
- Title: Subtitle
- Localization of a Medial Temporal Lobe - Precuneus Network for Time Orientation
- Creators
- Jax Skye - University of IowaJoel Bruss - University of IowaGuillaume Herbet - Université de MontpellierDaniel Tranel - University of IowaAaron D Boes - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Annals of neurology, Vol.94(3), pp.421-433
- DOI
- 10.1002/ana.26681
- PMID
- 37183996
- PMCID
- PMC10524450
- NLM abbreviation
- Ann Neurol
- ISSN
- 0364-5134
- eISSN
- 1531-8249
- Publisher
- Wiley
- Grant note
- DOI: 10.13039/100000065, name: National Institute of Neurological Disorders and Stroke, award: 3R01NS114405, T32NS007421; DOI: 10.13039/100001024, name: Roy J. Carver Charitable Trust
- Language
- English
- Electronic publication date
- 05/15/2023
- Date published
- 09/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984410789402771
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