Journal article
Localization of a gene for non-syndromic hearing loss (DFNA5) to chromosome 7p15
Human molecular genetics, Vol.4(11), pp.2159-2163
11/1995
DOI: 10.1093/hmg/4.11.2159
PMID: 8589696
Abstract
Progressive hearing loss affects approximately 50% of the elderly by the age of 80, and is most likely caused by an interaction of genetic and environmental factors. Identification of the genes responsible for hereditary hearing loss is therefore important. Families with pure genetic degenerative hearing disorders may be helpful as the same genes may be also involved in age-related hearing loss in general. In this study we have performed a genome search in an extended Dutch family with autosomal dominant progressive hearing loss starting in the high frequencies. The gene causing hearing loss in this family was localized to the short arm of chromosome 7, in a 15 cM interval between markers D7S493 and D7S632.
Details
- Title: Subtitle
- Localization of a gene for non-syndromic hearing loss (DFNA5) to chromosome 7p15
- Creators
- G van Camp - Department of Medical Genetics, University of Antwerp (UIA), BelgiumP CouckeW BalemansD van VelzenC van de BiltL van LaerR J SmithK FukushimaG W PadbergR R Frants
- Resource Type
- Journal article
- Publication Details
- Human molecular genetics, Vol.4(11), pp.2159-2163
- DOI
- 10.1093/hmg/4.11.2159
- PMID
- 8589696
- NLM abbreviation
- Hum Mol Genet
- ISSN
- 0964-6906
- eISSN
- 1460-2083
- Publisher
- England
- Language
- English
- Date published
- 11/1995
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984007199402771
Metrics
26 Record Views