Journal article
Localization of inflammation with 111In IgG and 99Tcm albumin colloid labelled leukocytes in a rabbit model
Nuclear medicine communications, Vol.11(11), pp.737-745
11/1990
DOI: 10.1097/00006231-199011000-00003
PMID: 2277689
Abstract
Localization of inflammation with two recently described radiotracers, 111In-labelled polyclonal IgG and 99Tcm albumin colloid labelled leukocytes (Tc-WBC), was studied. Accumulation of activity was compared with 111In-labelled leukocytes (In-WBC) using 131I human serum albumin as a control. Ratios of activity in a chemically induced abscess in the thigh of rabbits compared with normal muscle tissue were measured. The results showed that all agents localize in inflammation but Tc-WBC consistently localizes to a greater degree than the other agents. At 2 h the inflammed-to-normal ratios for Tc-WBC were 4, IgG 2.1, albumin 1.9 and In-WBC 1.7. The pattern of the ratios remained similar over the 18 h period of the study. The short time in which leukocytes can be labelled and the quality of the images obtained suggest that Tc-WBC imaging is the method of choice for this model.
Details
- Title: Subtitle
- Localization of inflammation with 111In IgG and 99Tcm albumin colloid labelled leukocytes in a rabbit model
- Creators
- H B Breitz - Division of Nuclear Medicine, University of Washington School of Medicine, Seattle 98195H I ModellM M Graham
- Resource Type
- Journal article
- Publication Details
- Nuclear medicine communications, Vol.11(11), pp.737-745
- Publisher
- England
- DOI
- 10.1097/00006231-199011000-00003
- PMID
- 2277689
- ISSN
- 0143-3636
- eISSN
- 1473-5628
- Language
- English
- Date published
- 11/1990
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984047729302771
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