Journal article
Localization of the Anterior Hypothalamic Angiotensin II Pressor System
Hypertension (Dallas, Tex. 1979), Vol.4(3 Suppl II), pp.II-159-II-165
05/1982
DOI: 10.1161/01.hyp.4.3.159
PMID: 7068204
Abstract
Previous studies by this laboratory hare shown that an electrolytic lesion of tissue surrounding the anterorentral third cerebral ventricle (AV3V) produces pressor deficits to both intravenously (i.v.) and intracerebrovenrricularly (i.c.v.) administered angioteosin II (All). These studies were designed to identify the neural substrates critical to the central All pressor response. The All pressor system was mapped employing a spectrum of overlapping electrolytic lesions within the medial preoptk-anterlor hypothalamic area. The effect of each lesion on the pressor response to AH (i.ev.) was tested in each animal, which was then grouped as a responder (R) or nonresponder (NR). The extent of damage produced by lesions that abolished the AH response was mapped. Bilateral destruction of tissue along the lamina tenninalis (LT) either below or at the level of the anterior commissure eliminated the AH pressor response as did destruction of tissue near the margin of the preoptic and anterior hypothalamic nuclei. These data suggested that an AH pressor pathway originating in the ventral A V3V region ascends along the LT to the level of the anterior commissure and then descends through the anterior hypotfaalamus. The path of the descending projection through the anterior hypothalamus was ascertained by making a series of horizontal knife cuts. Transections were found that effectively eliminated the central AH pressor response without impinging upon the LT. It is concluded that the anterior hypothalaraus contains an efferent pathway from the AV3V region associated with the central AH pressor response. (Hypertension 4 (suppl II)II-159-II-165, 1982)
Details
- Title: Subtitle
- Localization of the Anterior Hypothalamic Angiotensin II Pressor System
- Creators
- DIANE Hartle - From the Departments of Pharmacology and Psychology and The Cardiovascular Center, University of Iowa, Iowa City, IowaR LindALAN JohnsonMICHAEL Brody
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.4(3 Suppl II), pp.II-159-II-165
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.hyp.4.3.159
- PMID
- 7068204
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 05/1982
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213405302771
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